Administration of an aldose reductase inhibitor induces a decrease of collagen fluorescence in diabetic rats

G. Suarez, R. Rajaram, K. C. Bhuyan, A. L. Oronsky, J. A. Goidl

Research output: Contribution to journalArticlepeer-review

Abstract

As a consequence of an increased flux through the sorbitol pathway fructose levels rise in various tissues in diabetes. Also, in vitro nonenzymatic fructosylation of protein induces the generation of fluorescence at a rate 10 times greater than glucosylation. The administration of sorbinil, an aldose reductase inhibitor known to lower tissue fructose concentration, to experimental diabetic rats led to a decrease in the fluorescence related to advanced Maillard products in their skin collagen. This effect is consistent with the in vivo occurrence of nonenzymatic fructosylation of collagen. A potential pathogenetic role for this posttranslational modification in diabetic complications should be considered.

Original languageEnglish (US)
Pages (from-to)624-627
Number of pages4
JournalJournal of Clinical Investigation
Volume82
Issue number2
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Medicine(all)

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