L'ADMA est corrélée à l'insulinorésistance au stade précoce de diabète indépendamment de la CRP ultrasensible et de la masse grasse

Translated title of the contribution: ADMA is a correlate of insulin resistance in early-stage diabetes independent of hs-CRP and body adiposity

M. Nakhjavani, H. Karimi-Jafari, A. Esteghamati, O. Khalilzadeh, F. Asgarani, A. Ghadiri-Anari

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: It has been shown that insulin resistance is associated with a state of chronic low-grade inflammation. Furthermore, depletion of nitric oxide (NO) or ineffectiveness of NO-mediated vasodilator mechanisms are associated with arterial stiffness and progression of insulin resistance to type-2 diabetes. In this study, we decided to evaluate the association between asymmetric dimethylarginine ([ADMA], an endogenous NO synthase inhibitor), high-sensitivity C-reactive protein ([hs-CRP]; a marker of chronic inflammation) and insulin resistance in early-stage type-2 diabetes. Methods: A total of 40 diabetic patients and 40 age-, sex- and body mass index (BMI)-matched healthy adult volunteers were recruited in this case-control study. Diabetic patients were recently diagnosed and did not have a history of any diabetes-related complications. Fasting blood samples were obtained and fasting plasma glucose, cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, creatinine, insulin, ADMA and hs-CRP were measured. Homeostasis model assessment of insulin resistance (HOMA-IR) was also calculated. Results: ADMA (0.9 ± 0.2 vs 0.7 ± 0.2 μmol/L; p< 0.001) and hs-CRP (3.0 ± 2.1 vs 1.3 ± 1.0 mg/L; p<0.001) were significantly higher in diabetic participants vs healthy controls. Age- and sex-adjusted ADMA values were significantly (p<0.05) correlated with hs-CRP (r=0.279) and HOMA-IR (r=0.288) in diabetic patients. These associations were not significant in healthy controls. The association between ADMA and HOMA-IR in diabetic patients remained significant (r=0.255; p<0.05), after adjustment for BMI, waist circumference, serum lipids, and hs-CRP. In multivariate regression analysis, ADMA and hs-CRP were independently correlated with diabetes. Conclusion: In early-stage type-2 diabetic patients, ADMA is an independent predictor of insulin resistance. Our results could possibly point to an independent mechanism for contribution of ADMA in development of insulin resistance.

Translated title of the contributionADMA is a correlate of insulin resistance in early-stage diabetes independent of hs-CRP and body adiposity
Original languageFrench
Pages (from-to)303-308
Number of pages6
JournalAnnales d'Endocrinologie
Volume71
Issue number4
DOIs
StatePublished - Sep 2010
Externally publishedYes

Keywords

  • ADMA
  • Diabetes mellitus
  • HOMA
  • Hs-CRP
  • Insulin resistance

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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