Use of either incomplete Freund, alhydrogel, or pertussis vaccine as adjuvants together with rat thyroid extract (RATE) elicited neither antibodies nor thyroiditis when injected into Lewis rats. A complete Freund adjuvant emulsion with RATE gave inconsistent results. Multiple, spaced injections of such an emulsion elicited a severe thyroid reaction. Combination of pertussis vaccine with either incomplete Freund adjuvant or alhydrogel elicited moderate thyroiditis. The most marked thyroiditis was obtained using a combination of CFA and RATE emulsion and a separate injection of pertussis vaccine.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Jan 1970|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)