Adjuvants for the Production of Autoimmune Thyroiditis in the Rat

Frank J. Twarog, Ellen Kenney, Noel R. Rose

Research output: Contribution to journalArticle

Abstract

Use of either incomplete Freund, alhydrogel, or pertussis vaccine as adjuvants together with rat thyroid extract (RATE) elicited neither antibodies nor thyroiditis when injected into Lewis rats. A complete Freund adjuvant emulsion with RATE gave inconsistent results. Multiple, spaced injections of such an emulsion elicited a severe thyroid reaction. Combination of pertussis vaccine with either incomplete Freund adjuvant or alhydrogel elicited moderate thyroiditis. The most marked thyroiditis was obtained using a combination of CFA and RATE emulsion and a separate injection of pertussis vaccine.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume133
Issue number1
DOIs
StatePublished - Jan 1970

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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