Adjuvants for the Production of Autoimmune Thyroiditis in the Rat

Frank J. Twarog, Ellen Kenney, Noel R. Rose

Research output: Contribution to journalArticlepeer-review


Use of either incomplete Freund, alhydrogel, or pertussis vaccine as adjuvants together with rat thyroid extract (RATE) elicited neither antibodies nor thyroiditis when injected into Lewis rats. A complete Freund adjuvant emulsion with RATE gave inconsistent results. Multiple, spaced injections of such an emulsion elicited a severe thyroid reaction. Combination of pertussis vaccine with either incomplete Freund adjuvant or alhydrogel elicited moderate thyroiditis. The most marked thyroiditis was obtained using a combination of CFA and RATE emulsion and a separate injection of pertussis vaccine.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - Jan 1970
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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