Adjuvants for the Production of Autoimmune Thyroiditis in the Rat

Frank J. Twarog; Ellen Kenney; Noel R. Rose

doi:10.3181/00379727-133-34437

Adjuvants for the Production of Autoimmune Thyroiditis in the Rat

Frank J. Twarog, Ellen Kenney, Noel R. Rose

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Use of either incomplete Freund, alhydrogel, or pertussis vaccine as adjuvants together with rat thyroid extract (RATE) elicited neither antibodies nor thyroiditis when injected into Lewis rats. A complete Freund adjuvant emulsion with RATE gave inconsistent results. Multiple, spaced injections of such an emulsion elicited a severe thyroid reaction. Combination of pertussis vaccine with either incomplete Freund adjuvant or alhydrogel elicited moderate thyroiditis. The most marked thyroiditis was obtained using a combination of CFA and RATE emulsion and a separate injection of pertussis vaccine.

Original language	English (US)
Pages (from-to)	185-189
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	133
Issue number	1
DOIs	https://doi.org/10.3181/00379727-133-34437
State	Published - Jan 1970
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Adjuvants for the Production of Autoimmune Thyroiditis in the Rat",

abstract = "Use of either incomplete Freund, alhydrogel, or pertussis vaccine as adjuvants together with rat thyroid extract (RATE) elicited neither antibodies nor thyroiditis when injected into Lewis rats. A complete Freund adjuvant emulsion with RATE gave inconsistent results. Multiple, spaced injections of such an emulsion elicited a severe thyroid reaction. Combination of pertussis vaccine with either incomplete Freund adjuvant or alhydrogel elicited moderate thyroiditis. The most marked thyroiditis was obtained using a combination of CFA and RATE emulsion and a separate injection of pertussis vaccine.",

author = "Twarog, {Frank J.} and Ellen Kenney and Rose, {Noel R.}",

note = "Funding Information: Supported in part by U.S. Public Health Service Research Grants CA-05203 and CA-02357 from the National Cancer Institute, National Institutes of Health. 2 Funding Information: Supported by U. S. Public Health Service Training Grant 5-T1-AI 130.",

year = "1970",

month = jan,

doi = "10.3181/00379727-133-34437",

language = "English (US)",

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T1 - Adjuvants for the Production of Autoimmune Thyroiditis in the Rat

AU - Twarog, Frank J.

AU - Kenney, Ellen

AU - Rose, Noel R.

N1 - Funding Information: Supported in part by U.S. Public Health Service Research Grants CA-05203 and CA-02357 from the National Cancer Institute, National Institutes of Health. 2 Funding Information: Supported by U. S. Public Health Service Training Grant 5-T1-AI 130.

PY - 1970/1

Y1 - 1970/1

N2 - Use of either incomplete Freund, alhydrogel, or pertussis vaccine as adjuvants together with rat thyroid extract (RATE) elicited neither antibodies nor thyroiditis when injected into Lewis rats. A complete Freund adjuvant emulsion with RATE gave inconsistent results. Multiple, spaced injections of such an emulsion elicited a severe thyroid reaction. Combination of pertussis vaccine with either incomplete Freund adjuvant or alhydrogel elicited moderate thyroiditis. The most marked thyroiditis was obtained using a combination of CFA and RATE emulsion and a separate injection of pertussis vaccine.

AB - Use of either incomplete Freund, alhydrogel, or pertussis vaccine as adjuvants together with rat thyroid extract (RATE) elicited neither antibodies nor thyroiditis when injected into Lewis rats. A complete Freund adjuvant emulsion with RATE gave inconsistent results. Multiple, spaced injections of such an emulsion elicited a severe thyroid reaction. Combination of pertussis vaccine with either incomplete Freund adjuvant or alhydrogel elicited moderate thyroiditis. The most marked thyroiditis was obtained using a combination of CFA and RATE emulsion and a separate injection of pertussis vaccine.

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Adjuvants for the Production of Autoimmune Thyroiditis in the Rat

Abstract

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