Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion

Anthony V. Moorman, Claire Schwab, Emily Winterman, Jerry Hancock, Anna Castleton, Michelle Cummins, Brenda Gibson, Nick Goulden, Pam Kearns, Beki James, Amy A. Kirkwood, Donna Lancaster, Mabrouk Madi, Andrew McMillan, Jayashree Motwani, Alice Norton, Aengus O’Marcaigh, Katharine Patrick, Neha Bhatnagar, Amrana QureshiDeborah Richardson, Simone Stokley, Gordon Taylor, Frederik W. van Delft, John Moppett, Christine J. Harrison, Sujith Samarasinghe, Ajay Vora

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with an ABL-class fusion have a high risk of relapse on standard chemotherapy but are sensitive to tyrosine kinase inhibitors (TKI). In UKALL2011, we screened patients with post-induction MRD ≥1% and positive patients (12%) received adjuvant TKI. As the intervention started during UKALL2011, not all eligible patients were screened prospectively. Retrospective screening of eligible patients allowed the outcome of equivalent ABL-class patients who did and did not receive a TKI in first remission to be compared. ABL-class patients who received a TKI in first remission had a reduced risk of relapse/refractory disease: 0% vs. 63% at four years (P = 0·009).

Original languageEnglish (US)
Pages (from-to)844-851
Number of pages8
JournalBritish journal of haematology
Volume191
Issue number5
DOIs
StatePublished - Dec 2020

Keywords

  • ABL-class fusion
  • paediatric acute lymphoblastic leukaemia
  • prognostic factors
  • targeted therapy
  • tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Hematology

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