Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion

Anthony V. Moorman; Claire Schwab; Emily Winterman; Jerry Hancock; Anna Castleton; Michelle Cummins; Brenda Gibson; Nick Goulden; Pam Kearns; Beki James; Amy A. Kirkwood; Donna Lancaster; Mabrouk Madi; Andrew McMillan; Jayashree Motwani; Alice Norton; Aengus O’Marcaigh; Katharine Patrick; Neha Bhatnagar; Amrana Qureshi; Deborah Richardson; Simone Stokley; Gordon Taylor; Frederik W. van Delft; John Moppett; Christine J. Harrison; Sujith Samarasinghe; Ajay Vora

doi:10.1111/bjh.17093

Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion

Anthony V. Moorman, Claire Schwab, Emily Winterman, Jerry Hancock, Anna Castleton, Michelle Cummins, Brenda Gibson, Nick Goulden, Pam Kearns, Beki James, Amy A. Kirkwood, Donna Lancaster, Mabrouk Madi, Andrew McMillan, Jayashree Motwani, Alice Norton, Aengus O’Marcaigh, Katharine Patrick, Neha Bhatnagar, Amrana QureshiDeborah Richardson, Simone Stokley, Gordon Taylor, Frederik W. van Delft, John Moppett, Christine J. Harrison, Sujith Samarasinghe, Ajay Vora

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Patients with an ABL-class fusion have a high risk of relapse on standard chemotherapy but are sensitive to tyrosine kinase inhibitors (TKI). In UKALL2011, we screened patients with post-induction MRD ≥1% and positive patients (12%) received adjuvant TKI. As the intervention started during UKALL2011, not all eligible patients were screened prospectively. Retrospective screening of eligible patients allowed the outcome of equivalent ABL-class patients who did and did not receive a TKI in first remission to be compared. ABL-class patients who received a TKI in first remission had a reduced risk of relapse/refractory disease: 0% vs. 63% at four years (P = 0·009).

Original language	English (US)
Pages (from-to)	844-851
Number of pages	8
Journal	British journal of haematology
Volume	191
Issue number	5
DOIs	https://doi.org/10.1111/bjh.17093
State	Published - Dec 2020

Keywords

ABL-class fusion
paediatric acute lymphoblastic leukaemia
prognostic factors
targeted therapy
tyrosine kinase inhibitor

ASJC Scopus subject areas

Hematology

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10.1111/bjh.17093

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Moorman, A. V., Schwab, C., Winterman, E., Hancock, J., Castleton, A., Cummins, M., Gibson, B., Goulden, N., Kearns, P., James, B., Kirkwood, A. A., Lancaster, D., Madi, M., McMillan, A., Motwani, J., Norton, A., O’Marcaigh, A., Patrick, K., Bhatnagar, N., ... Vora, A. (2020). Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion. British journal of haematology, 191(5), 844-851. https://doi.org/10.1111/bjh.17093

Moorman, AV, Schwab, C, Winterman, E, Hancock, J, Castleton, A, Cummins, M, Gibson, B, Goulden, N, Kearns, P, James, B, Kirkwood, AA, Lancaster, D, Madi, M, McMillan, A, Motwani, J, Norton, A, O’Marcaigh, A, Patrick, K, Bhatnagar, N, Qureshi, A, Richardson, D, Stokley, S, Taylor, G, van Delft, FW, Moppett, J, Harrison, CJ, Samarasinghe, S & Vora, A 2020, 'Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion', British journal of haematology, vol. 191, no. 5, pp. 844-851. https://doi.org/10.1111/bjh.17093

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title = "Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion",

abstract = "Patients with an ABL-class fusion have a high risk of relapse on standard chemotherapy but are sensitive to tyrosine kinase inhibitors (TKI). In UKALL2011, we screened patients with post-induction MRD ≥1% and positive patients (12%) received adjuvant TKI. As the intervention started during UKALL2011, not all eligible patients were screened prospectively. Retrospective screening of eligible patients allowed the outcome of equivalent ABL-class patients who did and did not receive a TKI in first remission to be compared. ABL-class patients who received a TKI in first remission had a reduced risk of relapse/refractory disease: 0% vs. 63% at four years (P = 0·009).",

keywords = "ABL-class fusion, paediatric acute lymphoblastic leukaemia, prognostic factors, targeted therapy, tyrosine kinase inhibitor",

author = "Moorman, {Anthony V.} and Claire Schwab and Emily Winterman and Jerry Hancock and Anna Castleton and Michelle Cummins and Brenda Gibson and Nick Goulden and Pam Kearns and Beki James and Kirkwood, {Amy A.} and Donna Lancaster and Mabrouk Madi and Andrew McMillan and Jayashree Motwani and Alice Norton and Aengus O{\textquoteright}Marcaigh and Katharine Patrick and Neha Bhatnagar and Amrana Qureshi and Deborah Richardson and Simone Stokley and Gordon Taylor and {van Delft}, {Frederik W.} and John Moppett and Harrison, {Christine J.} and Sujith Samarasinghe and Ajay Vora",

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doi = "10.1111/bjh.17093",

language = "English (US)",

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AU - Winterman, Emily

AU - Hancock, Jerry

AU - Castleton, Anna

AU - Cummins, Michelle

AU - Gibson, Brenda

AU - Goulden, Nick

AU - Kearns, Pam

AU - James, Beki

AU - Kirkwood, Amy A.

AU - Lancaster, Donna

AU - Madi, Mabrouk

AU - McMillan, Andrew

AU - Motwani, Jayashree

AU - Norton, Alice

AU - O’Marcaigh, Aengus

AU - Patrick, Katharine

AU - Bhatnagar, Neha

AU - Qureshi, Amrana

AU - Richardson, Deborah

AU - Stokley, Simone

AU - Taylor, Gordon

AU - van Delft, Frederik W.

AU - Moppett, John

AU - Harrison, Christine J.

AU - Samarasinghe, Sujith

AU - Vora, Ajay

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AB - Patients with an ABL-class fusion have a high risk of relapse on standard chemotherapy but are sensitive to tyrosine kinase inhibitors (TKI). In UKALL2011, we screened patients with post-induction MRD ≥1% and positive patients (12%) received adjuvant TKI. As the intervention started during UKALL2011, not all eligible patients were screened prospectively. Retrospective screening of eligible patients allowed the outcome of equivalent ABL-class patients who did and did not receive a TKI in first remission to be compared. ABL-class patients who received a TKI in first remission had a reduced risk of relapse/refractory disease: 0% vs. 63% at four years (P = 0·009).

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Adjuvant tyrosine kinase inhibitor therapy improves outcome for children and adolescents with acute lymphoblastic leukaemia who have an ABL-class fusion

Abstract

Keywords

ASJC Scopus subject areas

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