TY - JOUR
T1 - Adjuvant therapy for resected non-small-cell lung cancer
T2 - Past, present, and future
AU - Juergens, Rosalyn A.
AU - Brahmer, Julie R.
PY - 2005/7
Y1 - 2005/7
N2 - Non-small-cell lung cancer has the highest mortality of all malignancies worldwide. Unfortunately, only the minority of patients diagnosed will have potentially curable disease. Over the past 30 years, dozens of trials have been conducted assessing adjuvant treatments to augment the survival advantage offered by surgery. It has only been in the past 5 years that promising results have begun to be seen. Cisplatin-based therapy has now been shown to provide an additional survival benefit in several trials and in a recent meta-analysis. The goal of this paper is to review the data on adjuvant therapies that have emerged over the past 30 years, focusing specifically on the trials that have been published in the past 5 years.
AB - Non-small-cell lung cancer has the highest mortality of all malignancies worldwide. Unfortunately, only the minority of patients diagnosed will have potentially curable disease. Over the past 30 years, dozens of trials have been conducted assessing adjuvant treatments to augment the survival advantage offered by surgery. It has only been in the past 5 years that promising results have begun to be seen. Cisplatin-based therapy has now been shown to provide an additional survival benefit in several trials and in a recent meta-analysis. The goal of this paper is to review the data on adjuvant therapies that have emerged over the past 30 years, focusing specifically on the trials that have been published in the past 5 years.
UR - http://www.scopus.com/inward/record.url?scp=23444449316&partnerID=8YFLogxK
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U2 - 10.1007/s11912-005-0046-5
DO - 10.1007/s11912-005-0046-5
M3 - Review article
C2 - 15946582
AN - SCOPUS:23444449316
SN - 1523-3790
VL - 7
SP - 248
EP - 254
JO - Current oncology reports
JF - Current oncology reports
IS - 4
ER -