Adjunctive high-dose glycine in the treatment of schizophrenia

Daniel C. Javitt, Gail Silipo, Angel Cienfuegos, Anne Marie Shelley, Nigel Bark, Mohan Park, Jean Pierre Lindenmayer, Ray Suckow, Stephen R. Zukin

Research output: Contribution to journalArticle

Abstract

Glycine is an agonist at brain N-methyl-D-aspartate receptors and crosses the blood-brain barrier following high-dose oral administration. In a previous study, significant improvements in negative and cognitive symptoms were observed in a group of 21 schizophrenic patients receiving high-dose glycine in addition to antipsychotic treatment. This study evaluated the degree to which symptom improvements might be related to alterations in antipsychotic drug levels in an additional group of 12 subjects. Glycine treatment was associated with an 8-fold increase in serum glycine levels, similar to that observed previously. A significant 34% reduction in negative symptoms was observed during glycine treatment. Serum antipsychotic levels were not significantly altered. Significant clinical effects were observed despite the fact that the majority of subjects were receiving atypical antipsychotics (clozapine or olanzapine). As in earlier studies, improvement persisted following glycine discontinuation.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalInternational Journal of Neuropsychopharmacology
Volume4
Issue number4
StatePublished - 2001
Externally publishedYes

Keywords

  • Cognition
  • Glutamate
  • Negative symptoms
  • NMDA receptors
  • Schizophrenia

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Javitt, D. C., Silipo, G., Cienfuegos, A., Shelley, A. M., Bark, N., Park, M., Lindenmayer, J. P., Suckow, R., & Zukin, S. R. (2001). Adjunctive high-dose glycine in the treatment of schizophrenia. International Journal of Neuropsychopharmacology, 4(4), 385-391.