Adiposity signaling and meal size control

Research output: Contribution to journalArticlepeer-review


Signaling from energy stores provides feedback on overall nutrient availability to influence food intake. Beginning with seminal studies by Woods and colleagues identifying insulin as an adiposity signal, it has become clear that such factors affect food intake by modulating the efficacy of within meal feedback satiety signals. More recent work with leptin has revealed actions of the hormone in modulating the efficacy of multiple gut feedback signals, identified the dorsal hindbrain as a site of signal integration and suggested both local and descending hypothalamic to hindbrain actions in mediating these effects. The original work by Woods and colleagues provided the necessary experimental paradigms for these advances.

Original languageEnglish (US)
Pages (from-to)21-24
Number of pages4
JournalPhysiology and Behavior
Issue number1
StatePublished - Apr 18 2011


  • Cholecystokinin
  • Insulin
  • Leptin
  • Satiety signaling

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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