Adiposity indices in the prediction of insulin resistance in prepubertal Colombian children

Noel T. Mueller, Mark A. Pereira, Adriana Buitrago-Lopez, Diana C. Rodríguez, Alvaro E. Duran, Alvaro J. Ruiz, Christian F. Rueda-Clausen, Cristina Villa-Roel

Research output: Contribution to journalArticle

Abstract

Objective To compare BMI with abdominal skinfold thickness (ASF), waist circumference and waist-to-height ratio in the prediction of insulin resistance (IR) in prepubertal Colombian children. Design We calculated age- and sex-specific Z-scores for BMI, ASF, waist circumference, waist-to-height ratio and three other skinfold-thickness sites. Logistic regression with stepwise selection (P = 0·80 for entry and P = 0·05 for retention) was performed to identify predictors of IR and extreme IR, which were determined by age- and sex-specific Z-scores to identify the ≥ 90th and ≥ 95th percentile of homeostasis model assessment (HOMAIR), respectively. We used receiver operating characteristic curves to compare the area under the curve between models. Setting Bucaramanga, Colombia. Subjects Children (n 1261) aged 6-10 years in Tanner stage 1 from a population-based study. Results A total of 127 children (seventy girls and fifty-seven boys) were classified with IR, including sixty-three children (thirty-three girls and thirty boys) classified with extreme IR. Only ASF and BMI Z-scores were retained as predictors of IR by stepwise selection. Adding ASF Z-score to BMI Z-score improved the area under the curve from 0·794 (95 % CI 0·752, 0·837) to 0·811 (95 % CI 0·770, 0·851; P for contrast = 0·01). In predicting extreme IR, the addition of ASF Z-score to BMI Z-score improved the area under the curve from 0·837 (95 % CI 0·790, 0·884) to 0·864 (95 % CI 0·823, 0·905; P for contrast = 0·01). Conclusions ASF Z-score predicted IR independent of BMI Z-score in our population of prepubertal children. ASF and BMI Z-scores together improved IR risk stratification compared with BMI Z-score alone, opening new perspectives in the prediction of cardiometabolic risk in prepubertal children.

Original languageEnglish (US)
Pages (from-to)248-255
Number of pages8
JournalPublic health nutrition
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2013
Externally publishedYes

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Keywords

  • Anthropometry
  • Body fat distribution
  • Growth
  • Insulin resistance
  • Obesity
  • Skinfold thickness
  • Waist circumference
  • Waist-to-height ratio

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

Cite this

Mueller, N. T., Pereira, M. A., Buitrago-Lopez, A., Rodríguez, D. C., Duran, A. E., Ruiz, A. J., Rueda-Clausen, C. F., & Villa-Roel, C. (2013). Adiposity indices in the prediction of insulin resistance in prepubertal Colombian children. Public health nutrition, 16(2), 248-255. https://doi.org/10.1017/S136898001200393X