Adipose Tissue Location and Contribution to Postinjury Hypercoagulability

Robert D. Winfield, Vincent M. Mellnick, Jad Chamieh, Eden Nohra, Wen Hui Tan, Ricardo Ramirez, Constantine Raptis, Isaiah R. Turnbull, Kelly Bochicchio, Stacey Reese, Philip C. Spinella, Grant V. Bochicchio

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVES: Obesity is associated with a hypercoagulable state at baseline and following injury. The anatomic location of adipose deposition may influence the type of thrombotic event, with visceral adipose tissue (VAT) associated with arterial thrombosis and subcutaneous adipose (SAT) predisposing to venous thrombosis. We sought to determine whether adipose tissue amount and location correlated with measures of coagulation. METHODS: All adult Level I Trauma Activations at our institution between January 2013 and August 2014 who underwent admission abdominal computed tomography (CT) scan and had admission rotational thromboelastometry (ROTEM) measurements were included. Patients were excluded for history of anticoagulant use and known coagulopathy/hypercoagulable state. Admission CT was used to obtain cross-sectional VAT and SAT areas at the umbilicus utilizing a novel software system; VAT and SAT measurements were associated with markers of coagulation utilizing Spearman’s correlation and stepwise linear regression with significance set at p

Original languageEnglish (US)
JournalThe journal of trauma and acute care surgery
DOIs
StateAccepted/In press - Apr 27 2016
Externally publishedYes

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Surgery

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