Adipose tissue as an endocrine organ

Rexford S. Ahima, Jeffery S. Flier

Research output: Contribution to journalReview articlepeer-review

1126 Scopus citations


The discovery of leptin in the mid-1990s has focused attention on the role of proteins secreted by adipose tissue. Leptin has profound effects on appetite and energy balance, and is also involved in the regulation of neuroendocrine and immune function. Sex steroid and glucocorticoid metabolism in adipose tissue has been implicated as a determinant of body fat distribution and cardiovascular risk. Other adipose products, for example, proinflammatory cytokines, complement factors and components of the coagulation/fibrinolytic cascade, may mediate the metabolic and cardiovascular complications associated with obesity.

Original languageEnglish (US)
Pages (from-to)327-332
Number of pages6
JournalTrends in Endocrinology and Metabolism
Issue number8
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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