Adiponectin protects rat hippocampal neurons against excitotoxicity

Guang Qiu, Ruiqian Wan, Jingping Hu, Mark P. Mattson, Edward Spangler, Shan Liu, Suk Yu Yau, Tatia M C Lee, Marc Gleichmann, Donald K. Ingram, Kwok Fai So, Sige Zou

Research output: Contribution to journalArticlepeer-review

Abstract

Adiponectin exerts multiple regulatory functions in the body and in the hypothalamus primarily through activation of its two receptors, adiponectin receptor1 and adiponectin receptor 2. Recent studies have shown that adiponectin receptors are widely expressed in other areas of the brain including the hippocampus. However, the functions of adiponectin in brain regions other than the hypothalamus are not clear. Here, we report that adiponectin can protect cultured hippocampal neurons against kainic acid-induced (KA) cytotoxicity. Adiponectin reduced the level of reactive oxygen species, attenuated apoptotic cell death, and also suppressed activation of caspase-3 induced by KA. Pretreatment of hippocampal primary neurons with an AMPK inhibitor, compound C, abolished adiponectin-induced neuronal protection. The AMPK activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, attenuated KA-induced caspase-3 activity. These findings suggest that the AMPK pathway is critically involved in adiponectin-induced neuroprotection and may mediate the antioxidative and anti-apoptotic properties of adiponectin.

Original languageEnglish (US)
Pages (from-to)155-165
Number of pages11
JournalAge
Volume33
Issue number2
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • Adiponectin
  • AMPK
  • Hippocampus
  • Kainic acid
  • Neuroprotection

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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