Adiponectin concentrations: A genome-wide association study

Sun Ha Jee, Jae Woong Sull, Jong Eun Lee, Chol Shin, Jongkeun Park, Heejin Kimm, Eun Young Cho, Eun Soon Shin, Ji Eun Yun, Ji Wan Park, Sang Yeun Kim, Sun Ju Lee, Eun Jung Jee, Inkyung Baik, Linda Kao, Sungjoo Kim Yoon, Yangsoo Jang, Terri H. Beaty

Research output: Contribution to journalArticle

Abstract

Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in CDH13 on chromosome 16 (p = 1.69 × 10-15 in the initial sample, p = 6.58 × 10-39 in the second genome-wide sample, and p = 2.12 × 10-32 in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10-83. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10-58) was even stronger in the third sample. A reporter assay that evaluated the effects of a CDH13 promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in CDH13 influence adiponectin levels in Korean adults.

Original languageEnglish (US)
Pages (from-to)545-552
Number of pages8
JournalAmerican journal of human genetics
Volume87
Issue number4
DOIs
StatePublished - Oct 8 2010

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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  • Cite this

    Jee, S. H., Sull, J. W., Lee, J. E., Shin, C., Park, J., Kimm, H., Cho, E. Y., Shin, E. S., Yun, J. E., Park, J. W., Kim, S. Y., Lee, S. J., Jee, E. J., Baik, I., Kao, L., Yoon, S. K., Jang, Y., & Beaty, T. H. (2010). Adiponectin concentrations: A genome-wide association study. American journal of human genetics, 87(4), 545-552. https://doi.org/10.1016/j.ajhg.2010.09.004