Adiponectin concentration in the orbital fat of patients with Ggraves' ophthalmopathy

Uri Soiberman; Ran Levy; Igal Leibovitch

doi:10.2147/OPTH.S49350

Adiponectin concentration in the orbital fat of patients with Ggraves' ophthalmopathy

Uri Soiberman, Ran Levy, Igal Leibovitch

Research output: Contribution to journal › Article › peer-review

Abstract

Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.

Original language	English (US)
Pages (from-to)	1723-1726
Number of pages	4
Journal	Clinical Ophthalmology
Volume	7
DOIs	https://doi.org/10.2147/OPTH.S49350
State	Published - Aug 24 2013
Externally published	Yes

Keywords

ELISA
Graves' disease
Graves' orbitopathy

ASJC Scopus subject areas

Ophthalmology

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10.2147/OPTH.S49350

Cite this

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abstract = "Background: {"}Graves' ophthalmopathy{"} (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.",

keywords = "ELISA, Graves' disease, Graves' orbitopathy",

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AU - Soiberman, Uri

AU - Levy, Ran

AU - Leibovitch, Igal

PY - 2013/8/24

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N2 - Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.

AB - Background: "Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim: The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods: This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results: The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion: This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.

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KW - Graves' disease

KW - Graves' orbitopathy

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Adiponectin concentration in the orbital fat of patients with Ggraves' ophthalmopathy

Abstract

Keywords

ASJC Scopus subject areas

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