Adipocytokines and the metabolic syndrome among older persons with and without obesity: The InCHIANTI study

Sari Stenholm, Annemarie Koster, Dawn E. Alley, Marjolein Visser, Marcello Maggio, Tamara B. Harris, Josephine M. Egan, Stefania Bandinelli, Jack M. Guralnik, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives Adipose tissue-derived inflammation may contribute to metabolic alterations and eventually to the metabolic syndrome (MetS). The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons. Design Cross-sectional population-based InCHIANTI study. Subjects A total of 944 community-dwelling adults aged 65 years and older living in Tuscany, Italy. Measurements Obesity was defined as body mass index ≥30 kg/m2 and MetS as ≥3 of the ATP-III criteria. Circulating levels of C-reactive protein, interleukin (IL)-6, IL-1 receptor antagonist (IL-1ra), IL-18, tumour necrosis factor (TNF)-α R1, adiponectin, resistin and leptin were measured. Additionally, insulin resistance was determined using the homeostasis model assessment (HOMA-IR). Results The prevalence of the MetS was 32%. Both overall and abdominal obesity were significantly associated with the MetS after adjusting for inflammatory cytokines, adipokines and lifestyle factors. After adjusting for multiple confounders and HOMA-IR, IL-1ra, TNF-α R1 and adiponectin (P <0·05) remained significantly associated with the MetS. Having multiple cytokines in the highest tertile increased the likelihood of having the MetS in both obese (P for trend 0·002) and non-obese persons (P for trend 0·001) independent of insulin resistance. Conclusions Non-obese and obese individuals who develop an intense pro-inflammatory state may be more prone to develop the MetS than those with lower levels of inflammation.

Original languageEnglish (US)
Pages (from-to)55-65
Number of pages11
JournalClinical Endocrinology
Volume73
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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