Adhesive and mammalian transglutaminase substrate properties of Candida albicans Hwp1

Janet F. Staab, Steven D. Bradway, Paul L. Fidel, Paula Sundstrom

Research output: Contribution to journalArticle

Abstract

The pathogenesis of candidiasis involves invasion of host tissues by filamentous forms of the opportunistic yeast Candida albicans. Morphology- specific gene products may confer proinvasive properties. A hypha-specific surface protein, Hwp1, with similarities to mammalian small proline-rich proteins was shown to serve as a substrate for mammalian transglutaminases. Candida albicans strains lacking Hwp1 were unable to form stable attachments to human buccal epithelial cells and had a reduced capacity to cause systemic candidiasis in mice. This represents a paradigm for microbial adhesion that implicates essential host enzymes.

Original languageEnglish (US)
Pages (from-to)1538
Number of pages1
JournalScience
Volume283
Issue number5407
DOIs
StatePublished - Mar 5 1999

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