Adhesion molecules in HIV-related and idiopathic polymyositis: Immunohistochemical studies

A. Carota, G. P. Pizzolato, M. Redard, Philippe Gailloud, G. E. Grau

Research output: Contribution to journalArticle

Abstract

Idiopathic polymyositis (IPM) and HIV polymyositis (HIV-PM) are considered to be related autoimmune diseases whose target is skeletal muscle. They have been associated to a T cell-mediated and MHC-I-restricted cytotoxic phenomenon, but both etiology and physiopathology remain incompletely understood. Their histological hallmarks are mononuclear leukocyte infiltrates as well as necrosis, degeneration, and regeneration of muscle fibers. In the present study, we have investigated the immunohistochemical expression of cell adhesion molecules, cytokines, and leukocyte surface antigens in biopsies of HIV-PM and IPM patients. The aim was to better define factors involved in lymphocyte recruitment and in inflammatory changes seen in PM. Notable upregulation of ICAM-1 and TNF-α was detected on capillary and venular endothelia and on inflammatory cells, whereas no significant VCAM-1 and ELAM-1 expression was present. LFA-1, the main ICAM-1 counter- receptor, was found to be highly expressed on lymphocytes and monocytes, especially at the vicinity of damaged fibers. The majority of infiltrating cells were CD8+CD45 RO-T cells, which are thought to have memory capacities. These findings suggest that in IPM and HIV-PM, enhanced ICAM-1 and LFA-1 expression possibly induced by TNF-α, may regulate the homing process of selected lymphocyte clones in muscle tissue. Lymphocyte proliferation and differentiation into memory subsets may further potentiate tissue-restricted homing capabilities.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalClinical Neuropathology
Volume16
Issue number6
StatePublished - Nov 1997
Externally publishedYes

Fingerprint

Polymyositis
HIV
Intercellular Adhesion Molecule-1
Lymphocytes
Lymphocyte Function-Associated Antigen-1
T-Lymphocytes
Mononuclear Leukocytes
Muscles
E-Selectin
Vascular Cell Adhesion Molecule-1
Vascular Endothelium
Cell Adhesion Molecules
Surface Antigens
HLA Antigens
Autoimmune Diseases
Regeneration
Monocytes
Skeletal Muscle
Necrosis
Up-Regulation

Keywords

  • Adhesion molecules
  • Cytokines
  • HIV
  • Polymyositis

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Adhesion molecules in HIV-related and idiopathic polymyositis : Immunohistochemical studies. / Carota, A.; Pizzolato, G. P.; Redard, M.; Gailloud, Philippe; Grau, G. E.

In: Clinical Neuropathology, Vol. 16, No. 6, 11.1997, p. 312-318.

Research output: Contribution to journalArticle

Carota, A, Pizzolato, GP, Redard, M, Gailloud, P & Grau, GE 1997, 'Adhesion molecules in HIV-related and idiopathic polymyositis: Immunohistochemical studies', Clinical Neuropathology, vol. 16, no. 6, pp. 312-318.
Carota, A. ; Pizzolato, G. P. ; Redard, M. ; Gailloud, Philippe ; Grau, G. E. / Adhesion molecules in HIV-related and idiopathic polymyositis : Immunohistochemical studies. In: Clinical Neuropathology. 1997 ; Vol. 16, No. 6. pp. 312-318.
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