Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts

E. C. Oelsner, T. D. Pottinger, K. M. Burkart, M. Allison, S. G. Buxbaum, N. N. Hansel, R. Kumar, E. K. Larkin, L. A. Lange, L. R. Loehr, S. J. London, G. T. O'Connor, G. Papanicolaou, M. F. Petrini, D. Rabinowitz, S. Raghavan, S. Redline, B. Thyagarajan, R. P. Tracy, J. B. WilkW. B. White, S. S. Rich, R. G. Barr

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown. Objective: Test associations of endothelial biomarkers with FEV1 using instrumental variables. Methods: Among 26907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets. Results: ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29mL and-34mL per standard deviation of log-transformed biomarker, p<0.001), as was endothelin-1 among African-Americans (-22mL, p=0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative. Conclusion: Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.

Original languageEnglish (US)
Pages (from-to)196-203
Number of pages8
JournalBiomarkers
Volume18
Issue number3
DOIs
StatePublished - May 2013
Externally publishedYes

Keywords

  • Genetic polymorphisms
  • Growth factors/cytokines/inflammatory mediators
  • Respiratory disease

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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