Adherence with Topical Glaucoma Medication Monitored Electronically. The Travatan Dosing Aid Study

Constance O. Okeke, Harry A. Quigley, Henry D. Jampel, Gui shuang Ying, Ryan J. Plyler, Yuzhen Jiang, David S. Friedman

Research output: Contribution to journalArticlepeer-review


Purpose: To assess patient adherence and behaviors with topical once-daily therapy for glaucoma. Design: Prospective, observational cohort study. Participants: One hundred ninety-six patients with glaucoma who were being treated with a prostaglandin analog in 1 or both eyes at the Scheie or Wilmer Eye Institutes between August 2006 and June 2007. Methods: Detailed medical history was obtained from each patient. All subjects used the Travatan Dosing Aid (DA; Alcon, Fort Worth, TX) to administer travoprost as prescribed. Devices were collected at 3 months and the data of drop usage was downloaded using software provided with the dosing aid. Data were analyzed for the 8-week period starting 2 weeks after the enrollment visit and ending 2 weeks before the 3-month visit. Main Outcome Measures: Assessment of adherence and patterns of drop usage as indicated by the DA. Results: A total of 282 subjects consented to be in the study and 86 (30%) withdrew before study completion or had device errors, leaving 196 subjects (70%) with evaluable data at 3 months. The overall mean (±standard deviation) adherence rate was 0.71 (±0.24), ranging from 0.02 to 0.97. One hundred nine of these patients (55.6%) took greater than 75% of the expected doses. Those with adherence of less than 50% of expected doses showed substantially increased dose taking immediately after the office visit and just before the return visit at 3 months (P = 0.03). The mean adherence rate estimates of the physician and patient self-report were 0.77 and 0.95, respectively. The agreement between the physician assessment and DA-recorded adherence rate showed poor correlation for individual cases (intraclass correlation coefficient, 0.09; 95% confidence interval, 0.00-0.19). Conclusions: Nearly 45% of patients using an electronic monitoring device who knew they were being monitored and were provided free medication used their drops less than 75% of the time. Patients reported far higher medication use than their actual behavior. The ability of the physician to identify which persons are poorly adherent from their self-report or from other subjective clues is poor. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references.

Original languageEnglish (US)
Pages (from-to)191-199
Number of pages9
Issue number2
StatePublished - Feb 2009

ASJC Scopus subject areas

  • Ophthalmology


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