Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission

Nicole L. Davis; William C. Miller; Michael G. Hudgens; Charles S. Chasela; Dorothy Sichali; Dumbani Kayira; Julie A E Nelson; Jeffrey S A Stringer; Sascha R. Ellington; Athena P. Kourtis; Denise J. Jamieson; Charles Van Der Horst; Linda Adair; Yusuf Ahmed; Mounir Ait-Khaled; Sandra Albrecht; Shrikant Bangdiwala; Ronald Bayer; Margaret Bentley; Brian Bramson; Emily Bobrow; Nicola Boyle; Sal Butera; Charity Chavula; Joseph Chimerang'ambe; Maggie Chigwenembe; Maria Chikasema; Norah Chikhungu; David Chilongozi; Grace Chiudzu; Lenesi Chome; Anne Cole; Amanda Corbett; Amy Corneli; Anna Dow; Ann Duerr; Henry Eliya; Joseph Eron; Sherry Farr; Yvonne Owens Ferguson; Susan Fiscus; Valerie Flax; Ali Fokar; Shannon Galvin; Laura Guay; Chad Heilig; Irving Hoffman; Elizabeth Hooten; Mina Hosseinipour; Stacy Hurst; Lisa Hyde; George Joaki; David Jones; Elizabeth Jordan-Bell; Zebrone Kacheche; Esmie Kamanga; Gift Kamanga; Coxcilly Kampani; Portia Kamthunzi; Deborah Kamwendo; Cecilia Kanyama; Angela Kashuba; Damson Kathyola; Peter Kazembe; Caroline C. King; Rodney Knight; Robert Krysiak; Jacob Kumwenda; Hana Lee; Edde Loeliger; Dustin Long; Misheck Luhanga; Victor Madhlopa; Maganizo Majawa; Alice Maida; Cheryl Marcus; Francis Martinson; Navdeep Thoofer; Chrissie Matiki; Douglas Mayers; Isabel Mayuni; Marita McDonough; Joyce Meme; Ceppie Merry; Khama Mita; Chimwemwe Mkomawanthu; Gertrude Mndala; Ibrahim Mndala; Agnes Moses; Albans Msika; Wezi Msungama; Beatrice Mtimuni; Jane Muita; Noel Mumba; Bonface Musis; Charles Mwansambo; Gerald Mwapasa; Jacqueline Nkhoma; Megan Parker; Richard Pendame; Ellen Piwoz; Byron Raines; Zane Ramdas; John Rublein; Mairin Ryan; Ian Sanne; Christopher Sellers; Diane Shugars; Wendy Snowden; Alice Soko; Allison Spensley; Jean Marc Steens; Gerald Tegha; Martin Tembo; Roshan Thomas; Hsiao Chuan Tien; Beth Tohill; Esther Waalberg; Elizabeth Widen; Jeffrey Wiener; Cathy Wilfert; Patricia Wiyo; Innocent Zgambo; Chifundo Zimba

doi:10.1097/QAD.0000000000000492

Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission

Nicole L. Davis, William C. Miller, Michael G. Hudgens, Charles S. Chasela, Dorothy Sichali, Dumbani Kayira, Julie A E Nelson, Jeffrey S A Stringer, Sascha R. Ellington, Athena P. Kourtis, Denise J. Jamieson, Charles Van Der Horst, Linda Adair, Yusuf Ahmed, Mounir Ait-Khaled, Sandra Albrecht, Shrikant Bangdiwala, Ronald Bayer, Margaret Bentley, Brian BramsonEmily Bobrow, Nicola Boyle, Sal Butera, Charity Chavula, Joseph Chimerang'ambe, Maggie Chigwenembe, Maria Chikasema, Norah Chikhungu, David Chilongozi, Grace Chiudzu, Lenesi Chome, Anne Cole, Amanda Corbett, Amy Corneli, Anna Dow, Ann Duerr, Henry Eliya, Joseph Eron, Sherry Farr, Yvonne Owens Ferguson, Susan Fiscus, Valerie Flax, Ali Fokar, Shannon Galvin, Laura Guay, Chad Heilig, Irving Hoffman, Elizabeth Hooten, Mina Hosseinipour, Stacy Hurst, Lisa Hyde, George Joaki, David Jones, Elizabeth Jordan-Bell, Zebrone Kacheche, Esmie Kamanga, Gift Kamanga, Coxcilly Kampani, Portia Kamthunzi, Deborah Kamwendo, Cecilia Kanyama, Angela Kashuba, Damson Kathyola, Peter Kazembe, Caroline C. King, Rodney Knight, Robert Krysiak, Jacob Kumwenda, Hana Lee, Edde Loeliger, Dustin Long, Misheck Luhanga, Victor Madhlopa, Maganizo Majawa, Alice Maida, Cheryl Marcus, Francis Martinson, Navdeep Thoofer, Chrissie Matiki, Douglas Mayers, Isabel Mayuni, Marita McDonough, Joyce Meme, Ceppie Merry, Khama Mita, Chimwemwe Mkomawanthu, Gertrude Mndala, Ibrahim Mndala, Agnes Moses, Albans Msika, Wezi Msungama, Beatrice Mtimuni, Jane Muita, Noel Mumba, Bonface Musis, Charles Mwansambo, Gerald Mwapasa, Jacqueline Nkhoma, Megan Parker, Richard Pendame, Ellen Piwoz, Byron Raines, Zane Ramdas, John Rublein, Mairin Ryan, Ian Sanne, Christopher Sellers, Diane Shugars, Wendy Snowden, Alice Soko, Allison Spensley, Jean Marc Steens, Gerald Tegha, Martin Tembo, Roshan Thomas, Hsiao Chuan Tien, Beth Tohill, Esther Waalberg, Elizabeth Widen, Jeffrey Wiener, Cathy Wilfert, Patricia Wiyo, Innocent Zgambo, Chifundo Zimba

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Objective: Estimate association between postpartum antiretroviral adherence and breast milk HIV-1 transmission. Design: Prospective cohort study. Methods: Mother-infant pairs were randomized after delivery to immediately begin receiving 28 weeks of either triple maternal antiretrovirals (zidovudine, lamivudine, and either nevirapine, nelfinavir, or lopinavir-ritonavir) or daily infant nevirapine as part of the Breastfeeding, Antiretrovirals, and Nutrition (BAN) study. Associations between postpartum antiretroviral adherence and rate of breast milk HIV-1 transmission were estimated using Coxmodels.Wemeasured adherence over four postpartumtimeintervals using pill count, suspension bottle weight, and maternal self-report. Adherence was categorized and lagged by one interval. Missing adherence measures were multiply imputed. Infant HIV-1 infection was determined by DNA PCR every 2-6 weeks. The primary endpoint was infant HIV-1 infection by 38 weeks of age among infants alive and uninfected at 5 weeks. Results: Analyses included 1479 mother-infant pairs and 45 transmission events. Using pill count and bottle weight information, 22-40% of mother-infant pairs at any given interval were less than 90% adherent. Having at least 90% adherence was associated with a 52% [95% confidence interval (CI) 3-76] relative reduction in the rate of breast milk HIV-1 transmission, compared with having less than 90% adherence when controlling for study arm, breastfeeding status, and maternal characteristics. Complete case analysis rendered similar results (n=501; relative reduction 59%, 95% CI 6-82). Conclusion: Nonadherence to extended postpartum antiretroviral regimens in 'real world' settings is likely to be higher than that seen in BAN. Identifying mothers with difficulty adhering to antiretrovirals, and developing effective adherence interventions, will help maximize benefits of antiretroviral provision throughout breastfeeding.

Original language	English (US)
Pages (from-to)	2739-2749
Number of pages	11
Journal	AIDS
Volume	28
Issue number	18
DOIs	https://doi.org/10.1097/QAD.0000000000000492
State	Published - 2014
Externally published	Yes

Keywords

Adherence
Antiretroviral
Breastfeeding
HIV transmission
Prevention of mother-to-child HIV transmission

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

Access to Document

10.1097/QAD.0000000000000492

Cite this

Davis, N. L., Miller, W. C., Hudgens, M. G., Chasela, C. S., Sichali, D., Kayira, D., Nelson, J. A. E., Stringer, J. S. A., Ellington, S. R., Kourtis, A. P., Jamieson, D. J., Van Der Horst, C., Adair, L., Ahmed, Y., Ait-Khaled, M., Albrecht, S., Bangdiwala, S., Bayer, R., Bentley, M., ... Zimba, C. (2014). Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission. AIDS, 28(18), 2739-2749. https://doi.org/10.1097/QAD.0000000000000492

Davis, NL, Miller, WC, Hudgens, MG, Chasela, CS, Sichali, D, Kayira, D, Nelson, JAE, Stringer, JSA, Ellington, SR, Kourtis, AP, Jamieson, DJ, Van Der Horst, C, Adair, L, Ahmed, Y, Ait-Khaled, M, Albrecht, S, Bangdiwala, S, Bayer, R, Bentley, M, Bramson, B, Bobrow, E, Boyle, N, Butera, S, Chavula, C, Chimerang'ambe, J, Chigwenembe, M, Chikasema, M, Chikhungu, N, Chilongozi, D, Chiudzu, G, Chome, L, Cole, A, Corbett, A, Corneli, A, Dow, A, Duerr, A, Eliya, H, Eron, J, Farr, S, Ferguson, YO, Fiscus, S, Flax, V, Fokar, A, Galvin, S, Guay, L, Heilig, C, Hoffman, I, Hooten, E, Hosseinipour, M, Hurst, S, Hyde, L, Joaki, G, Jones, D, Jordan-Bell, E, Kacheche, Z, Kamanga, E, Kamanga, G, Kampani, C, Kamthunzi, P, Kamwendo, D, Kanyama, C, Kashuba, A, Kathyola, D, Kazembe, P, King, CC, Knight, R, Krysiak, R, Kumwenda, J, Lee, H, Loeliger, E, Long, D, Luhanga, M, Madhlopa, V, Majawa, M, Maida, A, Marcus, C, Martinson, F, Thoofer, N, Matiki, C, Mayers, D, Mayuni, I, McDonough, M, Meme, J, Merry, C, Mita, K, Mkomawanthu, C, Mndala, G, Mndala, I, Moses, A, Msika, A, Msungama, W, Mtimuni, B, Muita, J, Mumba, N, Musis, B, Mwansambo, C, Mwapasa, G, Nkhoma, J, Parker, M, Pendame, R, Piwoz, E, Raines, B, Ramdas, Z, Rublein, J, Ryan, M, Sanne, I, Sellers, C, Shugars, D, Snowden, W, Soko, A, Spensley, A, Steens, JM, Tegha, G, Tembo, M, Thomas, R, Tien, HC, Tohill, B, Waalberg, E, Widen, E, Wiener, J, Wilfert, C, Wiyo, P, Zgambo, I & Zimba, C 2014, 'Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission', AIDS, vol. 28, no. 18, pp. 2739-2749. https://doi.org/10.1097/QAD.0000000000000492

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title = "Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission",

abstract = "Objective: Estimate association between postpartum antiretroviral adherence and breast milk HIV-1 transmission. Design: Prospective cohort study. Methods: Mother-infant pairs were randomized after delivery to immediately begin receiving 28 weeks of either triple maternal antiretrovirals (zidovudine, lamivudine, and either nevirapine, nelfinavir, or lopinavir-ritonavir) or daily infant nevirapine as part of the Breastfeeding, Antiretrovirals, and Nutrition (BAN) study. Associations between postpartum antiretroviral adherence and rate of breast milk HIV-1 transmission were estimated using Coxmodels.Wemeasured adherence over four postpartumtimeintervals using pill count, suspension bottle weight, and maternal self-report. Adherence was categorized and lagged by one interval. Missing adherence measures were multiply imputed. Infant HIV-1 infection was determined by DNA PCR every 2-6 weeks. The primary endpoint was infant HIV-1 infection by 38 weeks of age among infants alive and uninfected at 5 weeks. Results: Analyses included 1479 mother-infant pairs and 45 transmission events. Using pill count and bottle weight information, 22-40% of mother-infant pairs at any given interval were less than 90% adherent. Having at least 90% adherence was associated with a 52% [95% confidence interval (CI) 3-76] relative reduction in the rate of breast milk HIV-1 transmission, compared with having less than 90% adherence when controlling for study arm, breastfeeding status, and maternal characteristics. Complete case analysis rendered similar results (n=501; relative reduction 59%, 95% CI 6-82). Conclusion: Nonadherence to extended postpartum antiretroviral regimens in 'real world' settings is likely to be higher than that seen in BAN. Identifying mothers with difficulty adhering to antiretrovirals, and developing effective adherence interventions, will help maximize benefits of antiretroviral provision throughout breastfeeding.",

keywords = "Adherence, Antiretroviral, Breastfeeding, HIV transmission, Prevention of mother-to-child HIV transmission",

author = "Davis, {Nicole L.} and Miller, {William C.} and Hudgens, {Michael G.} and Chasela, {Charles S.} and Dorothy Sichali and Dumbani Kayira and Nelson, {Julie A E} and Stringer, {Jeffrey S A} and Ellington, {Sascha R.} and Kourtis, {Athena P.} and Jamieson, {Denise J.} and {Van Der Horst}, Charles and Linda Adair and Yusuf Ahmed and Mounir Ait-Khaled and Sandra Albrecht and Shrikant Bangdiwala and Ronald Bayer and Margaret Bentley and Brian Bramson and Emily Bobrow and Nicola Boyle and Sal Butera and Charity Chavula and Joseph Chimerang'ambe and Maggie Chigwenembe and Maria Chikasema and Norah Chikhungu and David Chilongozi and Grace Chiudzu and Lenesi Chome and Anne Cole and Amanda Corbett and Amy Corneli and Anna Dow and Ann Duerr and Henry Eliya and Joseph Eron and Sherry Farr and Ferguson, {Yvonne Owens} and Susan Fiscus and Valerie Flax and Ali Fokar and Shannon Galvin and Laura Guay and Chad Heilig and Irving Hoffman and Elizabeth Hooten and Mina Hosseinipour and Stacy Hurst and Lisa Hyde and George Joaki and David Jones and Elizabeth Jordan-Bell and Zebrone Kacheche and Esmie Kamanga and Gift Kamanga and Coxcilly Kampani and Portia Kamthunzi and Deborah Kamwendo and Cecilia Kanyama and Angela Kashuba and Damson Kathyola and Peter Kazembe and King, {Caroline C.} and Rodney Knight and Robert Krysiak and Jacob Kumwenda and Hana Lee and Edde Loeliger and Dustin Long and Misheck Luhanga and Victor Madhlopa and Maganizo Majawa and Alice Maida and Cheryl Marcus and Francis Martinson and Navdeep Thoofer and Chrissie Matiki and Douglas Mayers and Isabel Mayuni and Marita McDonough and Joyce Meme and Ceppie Merry and Khama Mita and Chimwemwe Mkomawanthu and Gertrude Mndala and Ibrahim Mndala and Agnes Moses and Albans Msika and Wezi Msungama and Beatrice Mtimuni and Jane Muita and Noel Mumba and Bonface Musis and Charles Mwansambo and Gerald Mwapasa and Jacqueline Nkhoma and Megan Parker and Richard Pendame and Ellen Piwoz and Byron Raines and Zane Ramdas and John Rublein and Mairin Ryan and Ian Sanne and Christopher Sellers and Diane Shugars and Wendy Snowden and Alice Soko and Allison Spensley and Steens, {Jean Marc} and Gerald Tegha and Martin Tembo and Roshan Thomas and Tien, {Hsiao Chuan} and Beth Tohill and Esther Waalberg and Elizabeth Widen and Jeffrey Wiener and Cathy Wilfert and Patricia Wiyo and Innocent Zgambo and Chifundo Zimba",

year = "2014",

doi = "10.1097/QAD.0000000000000492",

language = "English (US)",

volume = "28",

pages = "2739--2749",

journal = "AIDS",

issn = "0269-9370",

publisher = "Lippincott Williams and Wilkins",

number = "18",

}

TY - JOUR

T1 - Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission

AU - Davis, Nicole L.

AU - Miller, William C.

AU - Hudgens, Michael G.

AU - Chasela, Charles S.

AU - Sichali, Dorothy

AU - Kayira, Dumbani

AU - Nelson, Julie A E

AU - Stringer, Jeffrey S A

AU - Ellington, Sascha R.

AU - Kourtis, Athena P.

AU - Jamieson, Denise J.

AU - Van Der Horst, Charles

AU - Adair, Linda

AU - Ahmed, Yusuf

AU - Ait-Khaled, Mounir

AU - Albrecht, Sandra

AU - Bangdiwala, Shrikant

AU - Bayer, Ronald

AU - Bentley, Margaret

AU - Bramson, Brian

AU - Bobrow, Emily

AU - Boyle, Nicola

AU - Butera, Sal

AU - Chavula, Charity

AU - Chimerang'ambe, Joseph

AU - Chigwenembe, Maggie

AU - Chikasema, Maria

AU - Chikhungu, Norah

AU - Chilongozi, David

AU - Chiudzu, Grace

AU - Chome, Lenesi

AU - Cole, Anne

AU - Corbett, Amanda

AU - Corneli, Amy

AU - Dow, Anna

AU - Duerr, Ann

AU - Eliya, Henry

AU - Eron, Joseph

AU - Farr, Sherry

AU - Ferguson, Yvonne Owens

AU - Fiscus, Susan

AU - Flax, Valerie

AU - Fokar, Ali

AU - Galvin, Shannon

AU - Guay, Laura

AU - Heilig, Chad

AU - Hoffman, Irving

AU - Hooten, Elizabeth

AU - Hosseinipour, Mina

AU - Hurst, Stacy

AU - Hyde, Lisa

AU - Joaki, George

AU - Jones, David

AU - Jordan-Bell, Elizabeth

AU - Kacheche, Zebrone

AU - Kamanga, Esmie

AU - Kamanga, Gift

AU - Kampani, Coxcilly

AU - Kamthunzi, Portia

AU - Kamwendo, Deborah

AU - Kanyama, Cecilia

AU - Kashuba, Angela

AU - Kathyola, Damson

AU - Kazembe, Peter

AU - King, Caroline C.

AU - Knight, Rodney

AU - Krysiak, Robert

AU - Kumwenda, Jacob

AU - Lee, Hana

AU - Loeliger, Edde

AU - Long, Dustin

AU - Luhanga, Misheck

AU - Madhlopa, Victor

AU - Majawa, Maganizo

AU - Maida, Alice

AU - Marcus, Cheryl

AU - Martinson, Francis

AU - Thoofer, Navdeep

AU - Matiki, Chrissie

AU - Mayers, Douglas

AU - Mayuni, Isabel

AU - McDonough, Marita

AU - Meme, Joyce

AU - Merry, Ceppie

AU - Mita, Khama

AU - Mkomawanthu, Chimwemwe

AU - Mndala, Gertrude

AU - Mndala, Ibrahim

AU - Moses, Agnes

AU - Msika, Albans

AU - Msungama, Wezi

AU - Mtimuni, Beatrice

AU - Muita, Jane

AU - Mumba, Noel

AU - Musis, Bonface

AU - Mwansambo, Charles

AU - Mwapasa, Gerald

AU - Nkhoma, Jacqueline

AU - Parker, Megan

AU - Pendame, Richard

AU - Piwoz, Ellen

AU - Raines, Byron

AU - Ramdas, Zane

AU - Rublein, John

AU - Ryan, Mairin

AU - Sanne, Ian

AU - Sellers, Christopher

AU - Shugars, Diane

AU - Snowden, Wendy

AU - Soko, Alice

AU - Spensley, Allison

AU - Steens, Jean Marc

AU - Tegha, Gerald

AU - Tembo, Martin

AU - Thomas, Roshan

AU - Tien, Hsiao Chuan

AU - Tohill, Beth

AU - Waalberg, Esther

AU - Widen, Elizabeth

AU - Wiener, Jeffrey

AU - Wilfert, Cathy

AU - Wiyo, Patricia

AU - Zgambo, Innocent

AU - Zimba, Chifundo

PY - 2014

Y1 - 2014

N2 - Objective: Estimate association between postpartum antiretroviral adherence and breast milk HIV-1 transmission. Design: Prospective cohort study. Methods: Mother-infant pairs were randomized after delivery to immediately begin receiving 28 weeks of either triple maternal antiretrovirals (zidovudine, lamivudine, and either nevirapine, nelfinavir, or lopinavir-ritonavir) or daily infant nevirapine as part of the Breastfeeding, Antiretrovirals, and Nutrition (BAN) study. Associations between postpartum antiretroviral adherence and rate of breast milk HIV-1 transmission were estimated using Coxmodels.Wemeasured adherence over four postpartumtimeintervals using pill count, suspension bottle weight, and maternal self-report. Adherence was categorized and lagged by one interval. Missing adherence measures were multiply imputed. Infant HIV-1 infection was determined by DNA PCR every 2-6 weeks. The primary endpoint was infant HIV-1 infection by 38 weeks of age among infants alive and uninfected at 5 weeks. Results: Analyses included 1479 mother-infant pairs and 45 transmission events. Using pill count and bottle weight information, 22-40% of mother-infant pairs at any given interval were less than 90% adherent. Having at least 90% adherence was associated with a 52% [95% confidence interval (CI) 3-76] relative reduction in the rate of breast milk HIV-1 transmission, compared with having less than 90% adherence when controlling for study arm, breastfeeding status, and maternal characteristics. Complete case analysis rendered similar results (n=501; relative reduction 59%, 95% CI 6-82). Conclusion: Nonadherence to extended postpartum antiretroviral regimens in 'real world' settings is likely to be higher than that seen in BAN. Identifying mothers with difficulty adhering to antiretrovirals, and developing effective adherence interventions, will help maximize benefits of antiretroviral provision throughout breastfeeding.

AB - Objective: Estimate association between postpartum antiretroviral adherence and breast milk HIV-1 transmission. Design: Prospective cohort study. Methods: Mother-infant pairs were randomized after delivery to immediately begin receiving 28 weeks of either triple maternal antiretrovirals (zidovudine, lamivudine, and either nevirapine, nelfinavir, or lopinavir-ritonavir) or daily infant nevirapine as part of the Breastfeeding, Antiretrovirals, and Nutrition (BAN) study. Associations between postpartum antiretroviral adherence and rate of breast milk HIV-1 transmission were estimated using Coxmodels.Wemeasured adherence over four postpartumtimeintervals using pill count, suspension bottle weight, and maternal self-report. Adherence was categorized and lagged by one interval. Missing adherence measures were multiply imputed. Infant HIV-1 infection was determined by DNA PCR every 2-6 weeks. The primary endpoint was infant HIV-1 infection by 38 weeks of age among infants alive and uninfected at 5 weeks. Results: Analyses included 1479 mother-infant pairs and 45 transmission events. Using pill count and bottle weight information, 22-40% of mother-infant pairs at any given interval were less than 90% adherent. Having at least 90% adherence was associated with a 52% [95% confidence interval (CI) 3-76] relative reduction in the rate of breast milk HIV-1 transmission, compared with having less than 90% adherence when controlling for study arm, breastfeeding status, and maternal characteristics. Complete case analysis rendered similar results (n=501; relative reduction 59%, 95% CI 6-82). Conclusion: Nonadherence to extended postpartum antiretroviral regimens in 'real world' settings is likely to be higher than that seen in BAN. Identifying mothers with difficulty adhering to antiretrovirals, and developing effective adherence interventions, will help maximize benefits of antiretroviral provision throughout breastfeeding.

KW - Adherence

KW - Antiretroviral

KW - Breastfeeding

KW - HIV transmission

KW - Prevention of mother-to-child HIV transmission

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U2 - 10.1097/QAD.0000000000000492

DO - 10.1097/QAD.0000000000000492

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AN - SCOPUS:84927759209

SN - 0269-9370

VL - 28

SP - 2739

EP - 2749

JO - AIDS

JF - AIDS

IS - 18

ER -

Adherence to extended postpartum antiretrovirals is associated with decreased breast milk HIV-1 transmission

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