Adherence to early antiretroviral therapy: Results from HPTN 052, a phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples

Steven A. Safren, Kenneth H. Mayer, San San Ou, Marybeth McCauley, Beatriz Grinsztejn, Mina C. Hosseinipour, Nagalingeswaran Kumarasamy, Theresa Gamble, Irving Hoffman, David D Celentano, Ying Qing Chen, Myron S. Cohen

Research output: Contribution to journalArticle

Abstract

Background: Combination antiretroviral therapy (ART) for HIV-1-infected individuals prevents sexual transmission if viral load is suppressed. Methods: Participants were HIV-1-infected partners randomized to early ART (CD4 350-550) in HPTN052 (n 886, median follow-up 2.1 years), a clinical trial of early ART to prevent sexual transmission of HIV-1 in serodiscordant couples at 13 sites in 9 countries. Adherence was assessed through pill count (dichotomized at

Original languageEnglish (US)
Pages (from-to)234-240
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume69
Issue number2
DOIs
StatePublished - Jun 1 2015

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Secondary Prevention
HIV-1
Viral Load
Therapeutics
Clinical Trials

Keywords

  • adherence
  • ART for prevention
  • treatment as prevention

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Adherence to early antiretroviral therapy : Results from HPTN 052, a phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples. / Safren, Steven A.; Mayer, Kenneth H.; Ou, San San; McCauley, Marybeth; Grinsztejn, Beatriz; Hosseinipour, Mina C.; Kumarasamy, Nagalingeswaran; Gamble, Theresa; Hoffman, Irving; Celentano, David D; Chen, Ying Qing; Cohen, Myron S.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 69, No. 2, 01.06.2015, p. 234-240.

Research output: Contribution to journalArticle

Safren, Steven A. ; Mayer, Kenneth H. ; Ou, San San ; McCauley, Marybeth ; Grinsztejn, Beatriz ; Hosseinipour, Mina C. ; Kumarasamy, Nagalingeswaran ; Gamble, Theresa ; Hoffman, Irving ; Celentano, David D ; Chen, Ying Qing ; Cohen, Myron S. / Adherence to early antiretroviral therapy : Results from HPTN 052, a phase III, multinational randomized trial of ART to prevent HIV-1 sexual transmission in serodiscordant couples. In: Journal of Acquired Immune Deficiency Syndromes. 2015 ; Vol. 69, No. 2. pp. 234-240.
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