Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa

J. B. Nachega, D. M. Stein, D. A. Lehman, D. Hlatshwayo, R. Mothopeng, Richard E Chaisson, A. S. Karstaedt

Research output: Contribution to journalArticle

Abstract

Little is known about achievable levels of antiretroviral treatment (ART) adherence in resource-limited settings. We conducted a cross-sectional study of adherence among patients at Chris Hani Baragwanath Hospital's Adult HIV Clinic in Soweto, South Africa. Adherence was assessed using a 1-month, self-report questionnaire and was calculated as a ratio of doses taken to doses prescribed. The 66 patients studied had a mean age of 36.1 years, a median duration of ART use of 18 months, and an overall baseline median CD4+ cell count of 200/mm3 (IQR: 114-364). The adherence reported by these patients for the previous month was >95% for 58 patients (88%), 90-95% for 6 (9%) and, 95% and 88% of patients with ≤95% adherence) and the overall median CD4+ cell count rose to 324/mm3 (IQR: 193-510). High adherence and viral suppression are achievable for a significant proportion of HIV-infected patients taking ART in a resource-limited area such as Soweto, South Africa. Strategies to maximize adherence in this setting should emphasize ready access to affordable and simple ART regimens, as well as HIV education programs to help increase awareness and decrease disease stigmatization.

Original languageEnglish (US)
Pages (from-to)1053-1056
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume20
Issue number10
DOIs
StatePublished - Nov 2004

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South Africa
HIV
CD4 Lymphocyte Count
Patient Compliance
Stereotyping
Therapeutics
Self Report
Cross-Sectional Studies
Education

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Nachega, J. B., Stein, D. M., Lehman, D. A., Hlatshwayo, D., Mothopeng, R., Chaisson, R. E., & Karstaedt, A. S. (2004). Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Research and Human Retroviruses, 20(10), 1053-1056. https://doi.org/10.1089/aid.2004.20.1053

Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. / Nachega, J. B.; Stein, D. M.; Lehman, D. A.; Hlatshwayo, D.; Mothopeng, R.; Chaisson, Richard E; Karstaedt, A. S.

In: AIDS Research and Human Retroviruses, Vol. 20, No. 10, 11.2004, p. 1053-1056.

Research output: Contribution to journalArticle

Nachega, JB, Stein, DM, Lehman, DA, Hlatshwayo, D, Mothopeng, R, Chaisson, RE & Karstaedt, AS 2004, 'Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa', AIDS Research and Human Retroviruses, vol. 20, no. 10, pp. 1053-1056. https://doi.org/10.1089/aid.2004.20.1053
Nachega, J. B. ; Stein, D. M. ; Lehman, D. A. ; Hlatshwayo, D. ; Mothopeng, R. ; Chaisson, Richard E ; Karstaedt, A. S. / Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. In: AIDS Research and Human Retroviruses. 2004 ; Vol. 20, No. 10. pp. 1053-1056.
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