TY - JOUR
T1 - Adherence to antiretroviral therapy
T2 - an update of current concepts.
AU - Lucas, Gregory M.
AU - Wu, Albert W.
AU - Cheever, Laura W.
PY - 2004/12
Y1 - 2004/12
N2 - The remarkable effectiveness of combination antiretroviral therapy (CART) in the treatment of HIV infection has placed a high premium on long-term adherence to therapy. Adherence levels to CART among HIV-infected individuals are similar to adherence levels with chronic medical conditions, such as diabetes and hypertension. However, unlike chronic medical conditions, medication adherence that is insufficient to maintain suppression of HIV replication will lead to drug resistance. Combination antiretroviral therapy regimen complexity and side-effect burden are clearly linked to adherence and are likely to be the factors most amenable to intervention. Adherence interventions that are multifaceted, flexible, and protracted are the most likely to be successful. Owing to the great benefits of CART even the small to modest gains in adherence that are achievable with adherence programs may prove to be cost effective.
AB - The remarkable effectiveness of combination antiretroviral therapy (CART) in the treatment of HIV infection has placed a high premium on long-term adherence to therapy. Adherence levels to CART among HIV-infected individuals are similar to adherence levels with chronic medical conditions, such as diabetes and hypertension. However, unlike chronic medical conditions, medication adherence that is insufficient to maintain suppression of HIV replication will lead to drug resistance. Combination antiretroviral therapy regimen complexity and side-effect burden are clearly linked to adherence and are likely to be the factors most amenable to intervention. Adherence interventions that are multifaceted, flexible, and protracted are the most likely to be successful. Owing to the great benefits of CART even the small to modest gains in adherence that are achievable with adherence programs may prove to be cost effective.
UR - http://www.scopus.com/inward/record.url?scp=24144454708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=24144454708&partnerID=8YFLogxK
U2 - 10.1007/s11904-004-0027-6
DO - 10.1007/s11904-004-0027-6
M3 - Review article
C2 - 16091239
AN - SCOPUS:24144454708
SN - 1548-3568
VL - 1
SP - 172
EP - 180
JO - Current HIV/AIDS reports
JF - Current HIV/AIDS reports
IS - 4
ER -