Adherence to a healthy lifestyle and all-cause mortality in CKD

Ana C. Ricardo, Magdalena Madero, Wei Yang, Cheryl Anderson, Matthew Menezes, Michael J. Fischer, Mary Turyk, Martha L. Daviglus, James P. Lash

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Background and objective Among general populations, a healthy lifestyle has been associated with lower risk of death. This study evaluated this association in individuals with CKD. Design, setting, participants,&measurementsAtotal of 2288 participantswithCKD(estimatedGFR2 ormicroalbuminuria) in the ThirdNationalHealth andNutrition Examination Surveywere included. A weighted healthy lifestyle score was calculated (range, 24 to 15, with 15 indicating healthiest lifestyle) on the basis of the multivariable Cox proportional hazards model regression coefficients of the following lifestyle factors: smoking habit, bodymass index (BMI), physical activity, and diet.Main outcomewas all-causemortality, ascertained through December 31, 2006. Results Aftermedian follow-up of 13 years, 1319 participants had died. Compared with individuals in the lowest quartile of weighted healthy lifestyle score, adjusted hazard ratios (95% confidence intervals) of all-cause mortality were 0.53 (0.41-0.68), 0.52 (0.42-0.63), and 0.47 (0.38-0.60) for individuals in the second, third, and fourth quartiles, respectively. Mortality increased 30% among individuals with a BMI of 18.5 to 2 versus 22 to 2 (P

Original languageEnglish (US)
Pages (from-to)602-609
Number of pages8
JournalClinical Journal of the American Society of Nephrology
Issue number4
StatePublished - Apr 5 2013

ASJC Scopus subject areas

  • Nephrology
  • Transplantation
  • Epidemiology
  • Critical Care and Intensive Care Medicine


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