Abstract
Objectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence. Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10. Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists. Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 141-145 |
| Number of pages | 5 |
| Journal | Patient Preference and Adherence |
| Volume | 4 |
| State | Published - 2010 |
| Externally published | Yes |
Keywords
- Adherence
- Cost
- Efficacy
- Side effects
- Sublingual immunotherapy
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Social Sciences (miscellaneous)
- Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
- Health Policy
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Adherence issues related to sublingual immunotherapy as perceived by allergists. / Scurati, Silvia; Frati, Franco; Passalacqua, Gianni et al.
In: Patient Preference and Adherence, Vol. 4, 2010, p. 141-145.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Adherence issues related to sublingual immunotherapy as perceived by allergists
AU - Scurati, Silvia
AU - Frati, Franco
AU - Passalacqua, Gianni
AU - Puccinelli, Paola
AU - Hilaire, Cecile
AU - Incorvaia, Cristoforo
AU - D'Avino, Gennaro
AU - Comi, Rosa
AU - Lo Schiavo, Mario
AU - Pezzuto, Francesco
AU - Montera, Carmen
AU - Pio, Antonio
AU - Teresa Ielpo, Maria
AU - Cellini, Francesco
AU - Vicentini, Licia
AU - Pecorari, Roberto
AU - Aresu, Tiziana
AU - Capra, Lucetta
AU - De Benedictis, Elena
AU - Bombi, Claudio
AU - Zauli, Daniela
AU - Vanzi, Annarita
AU - Alberto Paltrinieri, Carlo
AU - Bondioli, Alfeo
AU - Paletta, Isabella
AU - Ventura, Domenica
AU - Mei, Francesco
AU - Paolini, Franco
AU - Colangelo, Caterina
AU - Cavallucci, Enrico
AU - Cucinelli, Francesco
AU - Tinari, Rosanna
AU - Ermini, Giuseppe
AU - Beltrami, Valerio
AU - Novembre, Elio
AU - Begliomini, Cinzia
AU - Marchese, Erminia
AU - Solito, Enrico
AU - Ammannati, Valentino
AU - Molino, Gaetanino
AU - Galli, Elena
AU - Baldassini, Mauro
AU - Di Michele, Loreta
AU - Calvani, Mauro
AU - Gidaro, Mirella
AU - Venuti, Alberto
AU - Li Bianchi, Enrico
AU - Benassi, Fulvio
AU - Pocobelli, Donatella
AU - Zangari, Paola
AU - De Rocco, Maria Grazia
AU - Lo Vecchio, Antonella
AU - Pingitore, Giuseppe
AU - Grimaldi, Orazio
AU - Schiavino, Domenico
AU - Perrone, Nicola
AU - Antonietta Frieri, Maria
AU - Di Rienzo, Valerio
AU - Tripodi, Salvatore
AU - Scarpa, Alessandro
AU - Tomsic, Mirala
AU - Bonaguro, Roberta
AU - Enrico Senna, Gian
AU - Sirena, Alberto
AU - Turatello, Franca
AU - Crescioli, Stefano
AU - Favero, Elisabetta
AU - Billeri, Lucia
AU - Chieco Bianchi, Fulvia
AU - Gemignani, Carla
AU - Zanforlin, Mario
AU - Angiola Crivellaro, Maria
AU - Hendrick, Birgir
AU - Maltauro, Adriana
AU - Masieri, Simonetta
AU - Elisabetta Conte, Maria
AU - Fama, Mario
AU - Pozzan, Marcella
AU - Bonadonna, Patrizia
AU - Casanova, Stefania
AU - Vallerani, Elisabetta
AU - Schiappoli, Michele
AU - Borghesan, Franco
AU - Giro, Giuseppina
AU - Casotto, Stefano
AU - Berardino, Loredana
AU - Zanoni, Giovanna
AU - Ariano, Renato
AU - Aquilina, Riccardo
AU - Pellegrino, Renato
AU - Marsico, Pietro
AU - Del Giudice, Angelica
AU - Narzisi, Giuseppe
AU - Tomaselli, Valerio
AU - Fornaca, Gianfranco
AU - Favro, Mauro
AU - Loperfido, Bruna
AU - Gallo, Cesare
AU - Buffoni, Sebastiano
AU - Gani, Federica
AU - Raviolo, Paolo
AU - Faggionato, Stefano
AU - Truffelli, Tiziana
AU - Vivalda, Livio
AU - Albano, Monica
AU - Enzo Rossi, Renato
AU - Lattuada, Giovanni
AU - Bona, Fausto
AU - Quaglio, Luisella
AU - Chiesa, Adriana
AU - Trapani, Marco
AU - Seminara, Rosalba
AU - Cucchi, Beniamino
AU - Oderda, Silvana
AU - Borio, Giovanni
AU - Galeasso, Giuseppe
AU - Garbaccio, Paolo
AU - De Marco, Antonino
AU - Marengo, Fulvia
AU - Cadario, Gianni
AU - Manzoni, Silvia
AU - Vinay, Claudio
AU - Curcio, Antonio
AU - Silvestri, Alberto
AU - Peduto, Antonella
AU - Riario-Sforza, Gian Galeazzo
AU - Maria Forgnone, Anna
AU - Barocelli, Piercarlo
AU - Tartaglia, Nicoletta
AU - Feyles, Gianfranco
AU - Giacone, Adriana
AU - Ricca, Vittorio
AU - Guida, Giuseppe
AU - Nebiolo, Franco
AU - Bommarito, Luisa
AU - Heffler, Enrico
AU - Vietti, Felice
AU - Galimberti, Maurizio
AU - Savi, Eleonora
AU - Pappacoda, Antonio
AU - Bottero, Paolo
AU - Porcu, Stefania
AU - Felice, Giuseppe
AU - Berra, Daniele
AU - Francesca Spina, Maria
AU - Pravettoni, Valerio
AU - Calamari, Ambra M.
AU - Varin, Elena
AU - Iemoli, Enrico
AU - Lietti, Daniele
AU - Ghiglioni, Daniele
AU - Fiocchi, Alessandro
AU - Tosi, Anna
AU - Poppa, Mariangela
AU - Caviglia, Antonio
AU - Restuccia, Massimo
AU - Russello, Marina
AU - Alciato, Paolo
AU - Manzotti, Giuseppina
AU - Ranghino, Emanuela
AU - Luraschi, Giorgio
AU - Rapetti, Andrea
AU - Rivolta, Federica
AU - Allegri, Flavio
AU - Terracciano, Luigi
AU - Agostinis, Fabio
AU - Paolo Piras, Pier
AU - Ronchi, Giuseppe
AU - Gaspardini, Giulio
AU - Caria, Vincenzo
AU - Tolu, Fortunato
AU - Fantasia, Dina
AU - Carta, Paola
AU - Moraschini, Anna
AU - Quilleri, Roberto
AU - Santelli, Antonietta
AU - Prandini, Paolo
AU - Del Giudice, Giorgia
AU - Apollonio, Aldo
AU - Bonazza, Lucio
AU - Teresa Franzini, Maria
AU - Branchi, Silvia
AU - Zanca, Mario
AU - Rinaldi, Sandro
AU - Catelli, Luca
AU - Zanoletti, Tullio
AU - Cosentino, Cristina
AU - Della Torre, Fabrizio
AU - Cremonte, Luigi
AU - Musazzi, Dario
AU - Suli, Claudia
AU - Rivolta, Loredana
AU - Ottolenghi, Anna
AU - Marino, Gianluca
AU - Sterza, Giuseppe
AU - Sambugaro, Renato
AU - Orlandini, Antonella
AU - Minale, Paola
AU - Voltolini, Susanna
AU - Bignardi, Donatella
AU - Omodeo, Pinuccia
AU - Tiri, Antonio
AU - Milani, Stefania
AU - Ronchi, Barbara
AU - Licardi, Giovanna
AU - Bruni, Paola
AU - Scibilia, Joseph
AU - Schroeder, Jan
AU - Crosti, Francesca
AU - Maltagliati, Angela
AU - Alesina, Maria R.
AU - Mosca, Marisa
AU - Leone, Gennaro
AU - Napolitano, Giorgio
AU - Di Gruttola, Giuseppe
AU - Scala, Guglielmo
AU - Mascio, Silvia
AU - Valente, Annamaria
AU - Marchetiello, Ilaria
AU - Catello, Romano
AU - Gazulli, Antonio
AU - Del Prete, Antonio
AU - Varricchio, Alfonso M.
AU - Carbone, Agostino
AU - Forestieri, Angelo
AU - Stillitano, Maria
AU - Leonetti, Luigi
AU - Tirroni, Enrico
AU - Castellano, Francesco
AU - Abbagnara, Francesco
AU - Romano, Francesco
AU - Levanti, Carmelo
AU - Cilia, Marcello
AU - Longo, Rocco
AU - Ferrari, Angelo
AU - Ferrari, Alberto
AU - Merenda, Roberto
AU - Di Ponti, Antonio
AU - Guercio, Enrico
AU - Surace, Lorenzo
AU - Ammendola, Giuseppe
AU - Tansella, Francesco
AU - Peccarisi, Lucia
AU - Stragapede, Lorenza
AU - Minenna, Michele
AU - Granato, Massimo
AU - Fuiano, Nicola
AU - Pannofino, Alessandro
AU - Ciuffreda, Simona
AU - Giannotta, Angela
AU - Morero, Giuseppe
AU - D'Oronzio, Lucia
AU - Taddeo, Giordano
AU - Nettis, Eustachio
AU - Cinquepalmi, Giuseppe
AU - Lamanna, Carlo
AU - Mastrandrea, Fulvio
AU - Minelli, Mauro
AU - Salamino, Francesco
AU - Muratore, Lionello
AU - Latorre, Francesco
AU - Quarta, Carlo
AU - Ventura, Maria
AU - D'Ippolito, Giannamaria
AU - Giannoccaro, Francesco
AU - Dambra, Porzia
AU - Pinto, Luigi
AU - Triggiani, Michele
AU - Munno, Giorgio
AU - Manfredi, Giacomo
AU - Lonero, Giuseppe
AU - Damiano, Vincenzo
AU - Errico, Giuseppe
AU - Di Leo, Elisabetta
AU - Manzari, Francesco
AU - Spagna, Virgilio
AU - Arsieni, Augusto
AU - Matarrese, Aurelia
AU - Mazzarella, Giuseppe
AU - Scarcia, Giovanni
AU - Scarano, Rosa
AU - Ferrannini, Antonio
AU - Pastore, Antonio
AU - Maionchi, Patrizia
AU - Filannino, Luigi
AU - Tria, Margherita
AU - Giuliano, Giampiero
AU - Damiani, Elisabetta
AU - Scichilone, Nicola
AU - Marchese, Margherita
AU - Lucania, Anna
AU - Marino, Mauro
AU - Strazzeri, Luigi
AU - Tumminello, Silvana
AU - Vitale, Giovanni I.
AU - Gulotta, Salvatore
AU - Gragotto, Giuseppe
AU - Zambito, Marcello
AU - Greco, Domenico
AU - Valenti, Giuseppe
AU - Licitra, Giorgio
AU - Cannata, Enzo
AU - Filpi, Rosalia
AU - Contraffatto, Mariarita
AU - Sichili, Stefania
AU - Randazzo, Salvatore
AU - Scarantino, Giovanna
AU - Lo Porto, Bruno
AU - Pavone, Franco
AU - Di Bartolo, Claudio
AU - Paternò, Antonino
AU - Rapisarda, Francesca
AU - Laudani, Erasmo
AU - Leonardi, Salvatore
AU - Padua, Vincenzo
AU - Cabibbo, Gaetano
AU - Marino Guzzardi, Giuseppe
AU - Deluca, Francesco
AU - Agozzino, Claudio
AU - Pettinato, Rosa
AU - Ghini, Marco
PY - 2010
Y1 - 2010
N2 - Objectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence. Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10. Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists. Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.
AB - Objectives: Sublingual immunotherapy (SLIT) is a viable alternative to subcutaneous immunotherapy to treat allergic rhinitis and asthma, and is widely used in clinical practice in many European countries. The clinical efficacy of SLIT has been established in a number of clinical trials and meta-analyses. However, because SLIT is self-administered by patients without medical supervision, the degree of patient adherence with treatment is still a concern. The objective of this study was to evaluate the perception by allergists of issues related to SLIT adherence. Methods: We performed a questionnaire-based survey of 296 Italian allergists, based on the adherence issues known from previous studies. The perception of importance of each item was assessed by a VAS scale ranging from 0 to 10. Results: Patient perception of clinical efficacy was considered the most important factor (ranked 1 by 54% of allergists), followed by the possibility of reimbursement (ranked 1 by 34%), and by the absence of side effects (ranked 1 by 21%). Patient education, regular follow-up, and ease of use of SLIT were ranked first by less than 20% of allergists. Conclusion: These findings indicate that clinical efficacy, cost, and side effects are perceived as the major issues influencing patient adherence to SLIT, and that further improvement of adherence is likely to be achieved by improving the patient information provided by prescribers.
KW - Adherence
KW - Cost
KW - Efficacy
KW - Side effects
KW - Sublingual immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=77954614858&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954614858&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:77954614858
SN - 1177-889X
VL - 4
SP - 141
EP - 145
JO - Patient Preference and Adherence
JF - Patient Preference and Adherence
ER -