Adenyl cyclase activity has been demonstrated in washed particles from ultrasonically disrupted platelets. NaF increased activity 10-fold and prostaglandin (PGE1) increased activity 18-fold. This is the first time a substance other than NaF has caused maximal stimulation of adenyl cyclase. Activation was found with PGE1 concentrations below 10-8M. The inhibitory effect of PGE1 on platelet aggregation may be related to activation of adenyl cyclase.
|Original language||English (US)|
|Number of pages||8|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Apr 29 1969|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology