Adenyl cyclase activity in human platelets

Sidney M. Wolfe; N. Raphael Shulman

doi:10.1016/0006-291X(69)90277-0

Adenyl cyclase activity in human platelets

Sidney M. Wolfe, N. Raphael Shulman

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Adenyl cyclase activity has been demonstrated in washed particles from ultrasonically disrupted platelets. NaF increased activity 10-fold and prostaglandin (PGE₁) increased activity 18-fold. This is the first time a substance other than NaF has caused maximal stimulation of adenyl cyclase. Activation was found with PGE₁ concentrations below 10^-8M. The inhibitory effect of PGE₁ on platelet aggregation may be related to activation of adenyl cyclase.

Original language	English (US)
Pages (from-to)	265-272
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	35
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(69)90277-0
State	Published - Apr 29 1969
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/0006-291X(69)90277-0

Cite this

@article{12f2cc5aa5fd4076a62c1a91a9f7c7f8,

title = "Adenyl cyclase activity in human platelets",

abstract = "Adenyl cyclase activity has been demonstrated in washed particles from ultrasonically disrupted platelets. NaF increased activity 10-fold and prostaglandin (PGE1) increased activity 18-fold. This is the first time a substance other than NaF has caused maximal stimulation of adenyl cyclase. Activation was found with PGE1 concentrations below 10-8M. The inhibitory effect of PGE1 on platelet aggregation may be related to activation of adenyl cyclase.",

author = "Wolfe, {Sidney M.} and Shulman, {N. Raphael}",

year = "1969",

month = apr,

day = "29",

doi = "10.1016/0006-291X(69)90277-0",

language = "English (US)",

volume = "35",

pages = "265--272",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Adenyl cyclase activity in human platelets

AU - Wolfe, Sidney M.

AU - Shulman, N. Raphael

PY - 1969/4/29

Y1 - 1969/4/29

N2 - Adenyl cyclase activity has been demonstrated in washed particles from ultrasonically disrupted platelets. NaF increased activity 10-fold and prostaglandin (PGE1) increased activity 18-fold. This is the first time a substance other than NaF has caused maximal stimulation of adenyl cyclase. Activation was found with PGE1 concentrations below 10-8M. The inhibitory effect of PGE1 on platelet aggregation may be related to activation of adenyl cyclase.

AB - Adenyl cyclase activity has been demonstrated in washed particles from ultrasonically disrupted platelets. NaF increased activity 10-fold and prostaglandin (PGE1) increased activity 18-fold. This is the first time a substance other than NaF has caused maximal stimulation of adenyl cyclase. Activation was found with PGE1 concentrations below 10-8M. The inhibitory effect of PGE1 on platelet aggregation may be related to activation of adenyl cyclase.

UR - http://www.scopus.com/inward/record.url?scp=0014694694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014694694&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(69)90277-0

DO - 10.1016/0006-291X(69)90277-0

M3 - Article

C2 - 4306327

AN - SCOPUS:0014694694

SN - 0006-291X

VL - 35

SP - 265

EP - 272

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Adenyl cyclase activity in human platelets

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this