Adenyl cyclase activity in human platelets

Sidney M. Wolfe, N. Raphael Shulman

Research output: Contribution to journalArticlepeer-review

124 Scopus citations


Adenyl cyclase activity has been demonstrated in washed particles from ultrasonically disrupted platelets. NaF increased activity 10-fold and prostaglandin (PGE1) increased activity 18-fold. This is the first time a substance other than NaF has caused maximal stimulation of adenyl cyclase. Activation was found with PGE1 concentrations below 10-8M. The inhibitory effect of PGE1 on platelet aggregation may be related to activation of adenyl cyclase.

Original languageEnglish (US)
Pages (from-to)265-272
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Apr 29 1969

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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