Adenoviruses isolated from wild gorillas are closely related to human species C viruses

McVey Duncan, Michael R. Cranfield, Holly Torano, Hubert M. Kuete, Grace P. Lee, Andrew Glenn, Joseph T. Bruder, David Rangel, Douglas E. Brough, Jason G. Gall

Research output: Contribution to journalArticle

Abstract

We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalVirology
Volume444
Issue number1-2
DOIs
StatePublished - Sep 1 2013

Keywords

  • Adenovirus
  • Evolution
  • Gorilla
  • Non-human primate
  • Viral vectors

ASJC Scopus subject areas

  • Virology

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  • Cite this

    Duncan, M., Cranfield, M. R., Torano, H., Kuete, H. M., Lee, G. P., Glenn, A., Bruder, J. T., Rangel, D., Brough, D. E., & Gall, J. G. (2013). Adenoviruses isolated from wild gorillas are closely related to human species C viruses. Virology, 444(1-2), 119-123. https://doi.org/10.1016/j.virol.2013.05.041