Adenoviruses isolated from wild gorillas are closely related to human species C viruses

McVey Duncan; Michael R. Cranfield; Holly Torano; Hubert M. Kuete; Grace P. Lee; Andrew Glenn; Joseph T. Bruder; David Rangel; Douglas E. Brough; Jason G. Gall

doi:10.1016/j.virol.2013.05.041

Adenoviruses isolated from wild gorillas are closely related to human species C viruses

McVey Duncan, Michael R. Cranfield, Holly Torano, Hubert M. Kuete, Grace P. Lee, Andrew Glenn, Joseph T. Bruder, David Rangel, Douglas E. Brough, Jason G. Gall

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors.

Original language	English (US)
Pages (from-to)	119-123
Number of pages	5
Journal	Virology
Volume	444
Issue number	1-2
DOIs	https://doi.org/10.1016/j.virol.2013.05.041
State	Published - Sep 2013
Externally published	Yes

Keywords

Adenovirus
Evolution
Gorilla
Non-human primate
Viral vectors

ASJC Scopus subject areas

Virology

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10.1016/j.virol.2013.05.041

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title = "Adenoviruses isolated from wild gorillas are closely related to human species C viruses",

abstract = "We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors.",

keywords = "Adenovirus, Evolution, Gorilla, Non-human primate, Viral vectors",

author = "McVey Duncan and Cranfield, {Michael R.} and Holly Torano and Kuete, {Hubert M.} and Lee, {Grace P.} and Andrew Glenn and Bruder, {Joseph T.} and David Rangel and Brough, {Douglas E.} and Gall, {Jason G.}",

year = "2013",

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doi = "10.1016/j.virol.2013.05.041",

language = "English (US)",

volume = "444",

pages = "119--123",

journal = "Virology",

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number = "1-2",

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T1 - Adenoviruses isolated from wild gorillas are closely related to human species C viruses

AU - Duncan, McVey

AU - Cranfield, Michael R.

AU - Torano, Holly

AU - Kuete, Hubert M.

AU - Lee, Grace P.

AU - Glenn, Andrew

AU - Bruder, Joseph T.

AU - Rangel, David

AU - Brough, Douglas E.

AU - Gall, Jason G.

PY - 2013/9

Y1 - 2013/9

N2 - We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors.

AB - We have isolated and cultured three distinct adenoviruses from wild gorillas. Phylogenetic analysis grouped the viruses with human adenovirus species C based on DNA polymerase, hexon, and E4ORF6 genes. The three wild gorilla adenoviruses clustered with the other species C captive gorilla adenoviruses, forming a branch separate from human and chimpanzee/bonobo adenoviruses. Animal sera to the three newly isolated viruses did not cross-neutralize, demonstrating serological distinctiveness. The human adenovirus 5 fiber knob blocked infection, suggesting use of the Coxsackie and Adenovirus Receptor. These viruses may provide viral vectors with properties distinct from chimpanzee adenovirus and human adenovirus vectors.

KW - Adenovirus

KW - Evolution

KW - Gorilla

KW - Non-human primate

KW - Viral vectors

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ER -

Adenoviruses isolated from wild gorillas are closely related to human species C viruses

Abstract

Keywords

ASJC Scopus subject areas

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