Adenosquamous carcinoma of the uncinate process of the pancreas with synchronous gastrointestinal stromal tumor of the stomach: Case report and review of the literature

Jin Jie He, Ke Feng Ding, Lei Zheng, Jing Hong Xu, Jun Li, Yu Lian Wu, Li Feng Sun, Dong Er Zhou, Shu Zheng

Research output: Contribution to journalArticle


Recently, the coexistence of gastrointestinal stromal tumors (GISTs) with other neoplasms has been studied with increasing frequency. Coexistence of pancreatic cancer with GISTs remains a rarity; however, here, we report a very rare case of adenosquamous carcinoma (ASC) of the uncinate process of the pancreas with synchronous GISTs of the stomach in a 62-year-old female. The patient presented with epigastric discomfort and vomiting. Radiographic imaging revealed two masses; one located at the body of the stomach and the other located at the uncinate process of the pancreas. Intraoperatively, a fine needle aspiration biopsy was conducted in the uncinate process of the pancreas, which revealed the malignancy of the masses. A pancreaticoduodenectomy and partial gastrectomy were then conducted, and subsequent pathological examinations identified an ASC of the pancreas and a GIST of the stomach. In our case, contrary to the majority of previous cases of synchronous GISTs and other malignancies, GIST was not an incidental finding. The initial suspicion on the GIST as the underlying cause of clinical symptoms led to the discovery of the ASC of the uncinate process of the pancreas.

Original languageEnglish (US)
Pages (from-to)1191-1194
Number of pages4
JournalOncology Letters
Issue number6
StatePublished - Dec 1 2012



  • Adenosquamous carcinoma
  • Gastrointestinal stromal tumor
  • Synchronous cancer
  • Uncinate process of the pancreas

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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