Adenosine receptors: Autoradiographic evidence for their location on axon terminals of excitatory neurons

Robert R. Goodman, Michael J. Kuhar, Lynda Hester, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Adenosine receptors were made visible on light microscopy by autoradiography with tritiated cyclohexyladenosine. In the cerebellum, adenosine receptors were absent in Weaver mice, which lack granule cells, and were displaced in Reeler mice, which have displacements of granule cells. Thus, adenosine receptors appear to be located on the axon terminals of excitatory granule cells in the cerebellum. Removal of one eye of a rat depleted adenosine receptors in the contralateral superior colliculus, suggesting that the receptors occur on axon terminals of excitatory projections from retinal ganglion cells. The presence of adenosine receptors on excitatory axon terminals may explain synaptic inhibition by adenosine and the behavioral effects of xanthines.

Original languageEnglish (US)
Pages (from-to)967-969
Number of pages3
JournalScience
Volume220
Issue number4600
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Adenosine receptors: Autoradiographic evidence for their location on axon terminals of excitatory neurons'. Together they form a unique fingerprint.

  • Cite this