Adenosine: Differential Effect on Blood Flow to Subregions of the Upper Gastrointestinal Tract

Marie F. Pennanen, Barbara L. Bass, Adam J. Dziki, John Harmon

Research output: Contribution to journalArticle

Abstract

The potential of adenosine to regulate organ blood flow (ml/min/100 g tissue) in the intact rabbit upper alimentary tract was evaluated using the radioactive microsphere technique. Adenosine (1.0 μmole/kg/min) produced significant, greater than threefold increases in esophageal mucosal blood flow (37 ± 2 to 127 ± 47) and threefold increases in antral mucosal (39 ± 3 to 144 ± 24) and transmural small intestinal blood flow (duodenum, 60 ± 13 to 187 ± 22; jejunum, 42 ± 3 to 138 ± 16; ileum, 27 ± 2 to 80 ± 22). Inosine did not reproduce these effects. P1-purinergic receptor antagonism with theophylline blocked the effects of adenosine. 5′-(N-Ethylcarboxamido)adenosine, an agonist of A2-subtype, P1-purinergic receptors, increased gastrointestinal organ blood flow similarly to adenosine with nmole/ kg/min doses. Similar doses of the A1-subtype agonist, N5-cyclohexyladenosine, were ineffective, but μmole/kg/min doses produced small effects on esophageal mucosa and ileum. Our results indicate that in rabbit alimentary organs, adenosine preferentially increases blood flow to esophageal mucosa, antral mucosa, and small intestine. Its effects are mediated by the A2-subtype of P1-purinergic receptors.

Original languageEnglish (US)
Pages (from-to)461-465
Number of pages5
JournalJournal of Surgical Research
Volume56
Issue number5
DOIs
StatePublished - May 1994
Externally publishedYes

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Upper Gastrointestinal Tract
Adenosine
Purinergic P1 Receptors
Ileum
varespladib methyl
Rabbits
Inosine
Jejunum
Theophylline
Microspheres
Duodenum
Small Intestine
Mucous Membrane

ASJC Scopus subject areas

  • Surgery

Cite this

Adenosine : Differential Effect on Blood Flow to Subregions of the Upper Gastrointestinal Tract. / Pennanen, Marie F.; Bass, Barbara L.; Dziki, Adam J.; Harmon, John.

In: Journal of Surgical Research, Vol. 56, No. 5, 05.1994, p. 461-465.

Research output: Contribution to journalArticle

Pennanen, Marie F. ; Bass, Barbara L. ; Dziki, Adam J. ; Harmon, John. / Adenosine : Differential Effect on Blood Flow to Subregions of the Upper Gastrointestinal Tract. In: Journal of Surgical Research. 1994 ; Vol. 56, No. 5. pp. 461-465.
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