Adenosine coronary vasodilation during hypoxia depends on adrenergic receptor activation

E. O. Feigl, F. Kajiya, J. Spaan, D. Kass

Research output: Contribution to journalArticle

Abstract

The adenosine hypothesis of coronary control was investigated during steady-state hypoxia by making measurements of coronary venous and epicardial well adenosine concentrations in adrenergically intact dogs and animals with α- and β-receptor blockade. The unexpected result was that a role for adenosine coronary vasodilation during hypoxia could only be found when adrenergic receptors were intact, but not during adrenergic blockade.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalAdvances in experimental medicine and biology
Volume346
StatePublished - Dec 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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