Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction - Results of a multicenter, randomized, placebo-controlled trial: The acute myocardial infarction STudy of ADenosine (AMISTAD) trial

Kenneth W. Mahaffey, Joseph A. Puma, N. Alejandro Barbagelata, Marcelo F. Dicarli, Massoud A. Leesar, Kevin F. Browne, Paul R. Eisenberg, Roberto Bolli, A. Cecilia Casas, Victor Molina-Viamonte, Cesare Orlandi, Roger Blevins, Raymond J. Gibbons, Robert M. Califf, Christopher B. Granger

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: The Acute Myocardial Infarction STudy of ADenosine (AMISTAD) trial was designed to test the hypothesis that adenosine as an adjunct to thrombolysis would reduce myocardial infarct size. BACKGROUND: Reperfusion therapy for acute myocardial infarction (MI) has been shown to reduce mortality, but reperfusion itself also may have deleterious effects. METHODS: The AMISTAD trial was a prospective, open-label trial of thrombolysis with randomization to adenosine or placebo in 236 patients within 6 h of infarction onset. The primary end point was infarct size as determined by Tc-99 m sestamibi single- photon emission computed tomography (SPECT) imaging 6 ± 1 days after enrollment based on multivariable regression modeling to adjust for covariates. Secondary end points were myocardial salvage index and a composite of in-hospital clinical outcomes (death, reinfarction, shock, congestive heart failure or stroke). RESULTS: In all, 236 patients were enrolled. Final infarct size was assessed in 197 (83%) patients. There was a 33% relative reduction in infarct size (p = 0.03) with adenosine. There was a 67% relative reduction in infarct size in patients with anterior infarction (15% in the adenosine group vs. 45.5% in the placebo group) but no reduction in patients with infarcts located elsewhere (11.5% for both groups). Patients randomized to adenosine tended to reach the composite clinical end point more often than those assigned to placebo (22% vs. 16%; odds ratio, 1.43; 95% confidence interval, 0.71 to 2.89). CONCLUSIONS: Many agents thought to attenuate reperfusion injury have been unsuccessful in clinical investigation. In this study, adenosine resulted in a significant reduction in infarct size. These data support the need for a large clinical outcome trial.

Original languageEnglish (US)
Pages (from-to)1711-1720
Number of pages10
JournalJournal of the American College of Cardiology
Volume34
Issue number6
DOIs
StatePublished - Nov 15 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Mahaffey, K. W., Puma, J. A., Barbagelata, N. A., Dicarli, M. F., Leesar, M. A., Browne, K. F., Eisenberg, P. R., Bolli, R., Casas, A. C., Molina-Viamonte, V., Orlandi, C., Blevins, R., Gibbons, R. J., Califf, R. M., & Granger, C. B. (1999). Adenosine as an adjunct to thrombolytic therapy for acute myocardial infarction - Results of a multicenter, randomized, placebo-controlled trial: The acute myocardial infarction STudy of ADenosine (AMISTAD) trial. Journal of the American College of Cardiology, 34(6), 1711-1720. https://doi.org/10.1016/S0735-1097(99)00418-0