Adenosine and anergy

Paul E. Zarek, Jonathan D. Powell

Research output: Contribution to journalReview articlepeer-review


T cells must integrate multiple environmental cues when deciding whether to mount an immunogenic or tolerogenic response. Since not all self-reactive T cells are eliminated during thymic development, mechanisms of peripheral tolerance such as T cell anergy contribute to preventing autoimmunity. Recent studies have implicated extracellular adenosine and the adenosine A2A receptor as playing an important role in inhibiting T cell effector function. Herein, we review the current literature regarding T cell anergy and the emerging literature implicating the A2A receptor as critical regulator of immune activation. Finally, we present evidence to suggest a possible role for adenosine A2A receptor signaling in T cell anergy.

Original languageEnglish (US)
Pages (from-to)425-432
Number of pages8
Issue number6
StatePublished - Sep 1 2007


  • Adenosine
  • Adenosine A receptor
  • Anergy
  • T cell
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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