Adenosine and anergy

Paul E. Zarek, Jonathan Powell

Research output: Contribution to journalArticle

Abstract

T cells must integrate multiple environmental cues when deciding whether to mount an immunogenic or tolerogenic response. Since not all self-reactive T cells are eliminated during thymic development, mechanisms of peripheral tolerance such as T cell anergy contribute to preventing autoimmunity. Recent studies have implicated extracellular adenosine and the adenosine A2A receptor as playing an important role in inhibiting T cell effector function. Herein, we review the current literature regarding T cell anergy and the emerging literature implicating the A2A receptor as critical regulator of immune activation. Finally, we present evidence to suggest a possible role for adenosine A2A receptor signaling in T cell anergy.

Original languageEnglish (US)
Pages (from-to)425-432
Number of pages8
JournalAutoimmunity
Volume40
Issue number6
DOIs
StatePublished - Sep 2007

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Adenosine
T-Lymphocytes
Adenosine A2A Receptors
Peripheral Tolerance
Autoimmunity
Cues

Keywords

  • Adenosine
  • Adenosine A receptor
  • Anergy
  • T cell
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Adenosine and anergy. / Zarek, Paul E.; Powell, Jonathan.

In: Autoimmunity, Vol. 40, No. 6, 09.2007, p. 425-432.

Research output: Contribution to journalArticle

Zarek, Paul E. ; Powell, Jonathan. / Adenosine and anergy. In: Autoimmunity. 2007 ; Vol. 40, No. 6. pp. 425-432.
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