Adeno-associated virus in normal and myositis human skeletal muscle

Z. Tezak, K. Nagaraju, P. Plotz, Eric P. Hoffman

Research output: Contribution to journalArticlepeer-review

Abstract

The normal tissue tropism of adeno-associated virus (AAV) is poorly defined, although the majority of humans test seropositive for this virus. Eighty-five muscle biopsy specimens were tested for AAV genomes; AAV DNA was identified in 17% of normal and 10% of Duchenne muscular dystrophy muscle biopsy specimens, but in only 3% of peripheral blood samples. AAV genomes were absent from all 37 muscle biopsy specimens from patients with myositis tested. Muscle is a major target organ for AAV, and infection is associated with autoimmune disease of muscle.

Original languageEnglish (US)
Pages (from-to)1913-1917
Number of pages5
JournalNeurology
Volume55
Issue number12
StatePublished - Dec 26 2000
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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