Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier

Ying Ying Wang, Samuel K. Lai, Jung Soo Suk, Amanda Pace, Richard Cone, Justin Hanes

Research output: Contribution to journalArticle

Abstract

(Figure Presented) Outsmarting the barrier: Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by adhesive interactions (red) with the mucus mesh (black lines). A dense, low molecular weight PEG coating (blue) uniquely endows nanoparticles with a mucoinert surface that enables their rapid mucus penetration (trajectory indicated by grey line).

Original languageEnglish (US)
Pages (from-to)9726-9729
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number50
DOIs
StatePublished - Dec 1 2008

Keywords

  • Drug delivery
  • Mucosal tissues
  • Nanomedicine
  • Particle tracking
  • Surface chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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