Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier

Ying Ying Wang; Samuel K. Lai; Jung Soo Suk; Amanda Pace; Richard Cone; Justin Hanes

doi:10.1002/anie.200803526

Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier

Ying Ying Wang, Samuel K. Lai, Jung Soo Suk, Amanda Pace, Richard Cone, Justin Hanes

School of Medicine

Research output: Contribution to journal › Article › peer-review

383 Scopus citations

Abstract

(Figure Presented) Outsmarting the barrier: Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by adhesive interactions (red) with the mucus mesh (black lines). A dense, low molecular weight PEG coating (blue) uniquely endows nanoparticles with a mucoinert surface that enables their rapid mucus penetration (trajectory indicated by grey line).

Original language	English (US)
Pages (from-to)	9726-9729
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	47
Issue number	50
DOIs	https://doi.org/10.1002/anie.200803526
State	Published - Dec 1 2008

Keywords

Drug delivery
Mucosal tissues
Nanomedicine
Particle tracking
Surface chemistry

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200803526

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abstract = "(Figure Presented) Outsmarting the barrier: Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by adhesive interactions (red) with the mucus mesh (black lines). A dense, low molecular weight PEG coating (blue) uniquely endows nanoparticles with a mucoinert surface that enables their rapid mucus penetration (trajectory indicated by grey line).",

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AU - Lai, Samuel K.

AU - Suk, Jung Soo

AU - Pace, Amanda

AU - Cone, Richard

AU - Hanes, Justin

PY - 2008/12/1

Y1 - 2008/12/1

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AB - (Figure Presented) Outsmarting the barrier: Conventional poly(ethylene glycol) (PEG) coated particles (green with light purple border) are immobilized in human mucus networks by adhesive interactions (red) with the mucus mesh (black lines). A dense, low molecular weight PEG coating (blue) uniquely endows nanoparticles with a mucoinert surface that enables their rapid mucus penetration (trajectory indicated by grey line).

KW - Drug delivery

KW - Mucosal tissues

KW - Nanomedicine

KW - Particle tracking

KW - Surface chemistry

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Addressing the PEG mucoadhesivity paradox to engineer nanoparticles that "slip" through the human mucus barrier

Abstract

Keywords

ASJC Scopus subject areas

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