TY - JOUR
T1 - Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain
AU - Bertolino, Alessandro
AU - Blasi, Giuseppe
AU - Latorre, Valeria
AU - Rubino, Valeria
AU - Rampino, Antonio
AU - Sinibaldi, Lorenzo
AU - Caforio, Grazia
AU - Petruzzella, Vittoria
AU - Pizzuti, Antonio
AU - Scarabino, Tommaso
AU - Nardini, Marcello
AU - Weinberger, Daniel R.
AU - Dallapiccola, Bruno
PY - 2006
Y1 - 2006
N2 - Functional polymorphisms in the catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT) genes modulate dopamine inactivation, which is crucial for determining neuronal signal-to-noise ratios in prefrontal cortex during working memory. We show that the COMT Met158 allele and the DAT 3′ variable number of tandem repeat 10-repeat allele are independently associated in healthy humans with more focused neuronal activity (as measured with blood oxygen level-dependent functional magnetic resonance imaging) in the working memory cortical network, including the prefrontal cortex. Moreover, subjects homozygous for the COMT Met allele and the DAT10-repeat allele have the most focused response, whereas the COMT Val and the DAT9-repeat alleles have the least. These results demonstrate additive genetic effects of genes regulating dopamine signaling on specific neuronal networks subserving working memory.
AB - Functional polymorphisms in the catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT) genes modulate dopamine inactivation, which is crucial for determining neuronal signal-to-noise ratios in prefrontal cortex during working memory. We show that the COMT Met158 allele and the DAT 3′ variable number of tandem repeat 10-repeat allele are independently associated in healthy humans with more focused neuronal activity (as measured with blood oxygen level-dependent functional magnetic resonance imaging) in the working memory cortical network, including the prefrontal cortex. Moreover, subjects homozygous for the COMT Met allele and the DAT10-repeat allele have the most focused response, whereas the COMT Val and the DAT9-repeat alleles have the least. These results demonstrate additive genetic effects of genes regulating dopamine signaling on specific neuronal networks subserving working memory.
KW - Anterior cingulate
KW - Catechol-O-methyltransferase
KW - Dopamine
KW - Dopamine transporter
KW - Dorsolateral prefrontal cortex
KW - Working memory
UR - http://www.scopus.com/inward/record.url?scp=33646117739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646117739&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.4975-05.2006
DO - 10.1523/JNEUROSCI.4975-05.2006
M3 - Article
C2 - 16611807
AN - SCOPUS:33646117739
SN - 0270-6474
VL - 26
SP - 3918
EP - 3922
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 15
ER -