Abstract
It is now recognised that the spectrum of antiphospholipid (aPL)-mediated syndromes includes end-organ injury due to microangiopathic manifestations. In the central nervous system (CNS), the clinical and radiographic appearance of microangiopathic lesions can be notoriously difficult to distinguish from multiple sclerosis (MS). A patient is presented who developed white-matter lesions in the brain and spinal-cord, shortly after receiving toxic doses of radiation for an arterio-venous malformation. The institution of interferon therapy for presumptive MS not only led to worsening neurologic deficits, but triggered a cutaneous syndrome with pleomorphic stigmata of microvascular injury (livedo reticularis rash, splinter haemorrhages). Subsequent workup revealed persistently elevated high-titer antiphospholipid of multiple isotypes. Treatment with corticosteroids and immunosuppressant therapy afforded improvement in locomotor function. We hypothesise that radiation injury and treatment with interferon-therapy constituted iatrogenic "hits" of endothelial injury, and potentiated aPL-mediated microangiopathic disease affecting the CNS and the skin.
Original language | English (US) |
---|---|
Pages (from-to) | 411-415 |
Number of pages | 5 |
Journal | Clinical and experimental rheumatology |
Volume | 28 |
Issue number | 3 |
State | Published - Dec 1 2010 |
Keywords
- Antiphospholipid antibody syndrome
- Neuropsychiatric disease
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology