Prior studies on the Johns Hopkins/Dana Foundation Bipolar Disorder Pedigrees, a series of 58 multiplex families, showed evidence of linkage to chromosome 18q21-22 with a paternal parent-of-origin effect (Stine et al., 1995; McMahon et al., 1997). Recently we reported that a clinically-defined subset of these families generated a peak paternal lodscore of 4.67 on 18q22 by multipoint affected sib pair linkage analysis (McMahon et al., in press). We have now added genotype data from 6 additional microsatellite markers in the linked region. This data was combined with the original set of markers to generate a set of 14 markers that could be unambiguously ordered on the finished sequence at a mean interval of 1.8 cM on 18q22. Linkage analysis was performed using the same sample and the same multipoint statistical methods as before. This analysis led to an increase in the peak paternal lodscore from 4.67 to 5.41, with a 1-lod support interval of 9 male cM. Our results support our previous findings and define an interval suitable for further studies aimed at identifying the genetic variation that accounts for the linkage evidence in this region.
|Original language||English (US)|
|Number of pages||2|
|Journal||American Journal of Medical Genetics - Neuropsychiatric Genetics|
|State||Published - Oct 8 2001|
ASJC Scopus subject areas
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience