Additional diagnostic yield of adding serology to PCR in diagnosing viral acute respiratory infections in Kenyan patients 5 years of age and older

Daniel R. Feikin, M. Kariuki Njenga, Godfrey Bigogo, Barrack Aura, Stella Gikunju, Amanda Balish, Mark A. Katz, Dean Erdman, Robert F. Breiman

Research output: Contribution to journalArticle

Abstract

The role of serology in the setting of PCR-based diagnosis of acute respiratory infections (ARIs) is unclear. We found that acute- and convalescent-phase paired-sample serologic testing increased the diagnostic yield of naso/oropharyngeal swabs for influenza virus, respiratory syncytial virus (RSV), human metapneumovirus, adenovirus, and parainfluenza viruses beyond PCR by 0.4% to 10.7%. Although still limited for clinical use, serology, along with PCR, can maximize etiologic diagnosis in epidemiologic studies.

Original languageEnglish (US)
Pages (from-to)113-114
Number of pages2
JournalClinical and Vaccine Immunology
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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