ADC values and prognosis of malignant astrocytomas: Does lower ADC predict a worse prognosis independent of grade of tumor?-a meta-analysis

Maria Zulfiqar; David M. Yousem; Hong Lai

doi:10.2214/AJR.12.8679

ADC values and prognosis of malignant astrocytomas: Does lower ADC predict a worse prognosis independent of grade of tumor?-a meta-analysis

Maria Zulfiqar, David M. Yousem, Hong Lai

School of Medicine

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

OBJECTIVE. The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS. Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS. The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and < 0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION. Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.

Original language	English (US)
Pages (from-to)	624-629
Number of pages	6
Journal	American Journal of Roentgenology
Volume	200
Issue number	3
DOIs	https://doi.org/10.2214/AJR.12.8679
State	Published - Mar 2013

Keywords

Apparent diffusion coefficient (ADC)
Astrocytoma
Brain tumor
Diffusion-weighted MRI
Glioblastoma

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.2214/AJR.12.8679

Cite this

@article{f1d939219e2d4e67a8b99ab050503fe4,

title = "ADC values and prognosis of malignant astrocytomas: Does lower ADC predict a worse prognosis independent of grade of tumor?-a meta-analysis",

abstract = "OBJECTIVE. The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS. Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS. The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and < 0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION. Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.",

keywords = "Apparent diffusion coefficient (ADC), Astrocytoma, Brain tumor, Diffusion-weighted MRI, Glioblastoma",

author = "Maria Zulfiqar and Yousem, {David M.} and Hong Lai",

year = "2013",

month = mar,

doi = "10.2214/AJR.12.8679",

language = "English (US)",

volume = "200",

pages = "624--629",

journal = "American Journal of Roentgenology",

issn = "0361-803X",

publisher = "American Roentgen Ray Society",

number = "3",

}

TY - JOUR

T1 - ADC values and prognosis of malignant astrocytomas

T2 - Does lower ADC predict a worse prognosis independent of grade of tumor?-a meta-analysis

AU - Zulfiqar, Maria

AU - Yousem, David M.

AU - Lai, Hong

PY - 2013/3

Y1 - 2013/3

N2 - OBJECTIVE. The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS. Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS. The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and < 0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION. Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.

AB - OBJECTIVE. The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS. Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS. The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and < 0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION. Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.

KW - Apparent diffusion coefficient (ADC)

KW - Astrocytoma

KW - Brain tumor

KW - Diffusion-weighted MRI

KW - Glioblastoma

UR - http://www.scopus.com/inward/record.url?scp=84876013157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876013157&partnerID=8YFLogxK

U2 - 10.2214/AJR.12.8679

DO - 10.2214/AJR.12.8679

M3 - Article

C2 - 23436853

AN - SCOPUS:84876013157

SN - 0361-803X

VL - 200

SP - 624

EP - 629

JO - American Journal of Roentgenology

JF - American Journal of Roentgenology

IS - 3

ER -

ADC values and prognosis of malignant astrocytomas: Does lower ADC predict a worse prognosis independent of grade of tumor?-a meta-analysis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this