ADC values and prognosis of malignant astrocytomas: Does lower ADC predict a worse prognosis independent of grade of tumor?-a meta-analysis

Research output: Contribution to journalArticle

Abstract

OBJECTIVE. The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS. Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS. The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and <0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION. Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.

Original languageEnglish (US)
Pages (from-to)624-629
Number of pages6
JournalAmerican Journal of Roentgenology
Volume200
Issue number3
DOIs
StatePublished - Mar 2013

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Astrocytoma
Meta-Analysis
Neoplasms

Keywords

  • Apparent diffusion coefficient (ADC)
  • Astrocytoma
  • Brain tumor
  • Diffusion-weighted MRI
  • Glioblastoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

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title = "ADC values and prognosis of malignant astrocytomas: Does lower ADC predict a worse prognosis independent of grade of tumor?-a meta-analysis",
abstract = "OBJECTIVE. The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS. Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS. The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and <0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION. Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.",
keywords = "Apparent diffusion coefficient (ADC), Astrocytoma, Brain tumor, Diffusion-weighted MRI, Glioblastoma",
author = "Maria Zulfiqar and Yousem, {David Mark} and Lai, {Hong Chen}",
year = "2013",
month = "3",
doi = "10.2214/AJR.12.8679",
language = "English (US)",
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pages = "624--629",
journal = "American Journal of Roentgenology",
issn = "0361-803X",
publisher = "American Roentgen Ray Society",
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TY - JOUR

T1 - ADC values and prognosis of malignant astrocytomas

T2 - Does lower ADC predict a worse prognosis independent of grade of tumor?-a meta-analysis

AU - Zulfiqar, Maria

AU - Yousem, David Mark

AU - Lai, Hong Chen

PY - 2013/3

Y1 - 2013/3

N2 - OBJECTIVE. The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS. Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS. The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and <0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION. Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.

AB - OBJECTIVE. The purpose of this article is to determine via meta-analysis whether apparent diffusion coefficient (ADC) predicts astrocytoma prognosis independent of grade. MATERIALS AND METHODS. Survival data were subjected to Mantel Haenszel analysis in four qualifying studies. Stratification by tumor grade was also performed. RESULTS. The survival rates of malignant astrocytomas, grade 3 and 4 (p, 0.004 and <0.0001, respectively) were worse below a specific ADC value, independent of grade. CONCLUSION. Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.

KW - Apparent diffusion coefficient (ADC)

KW - Astrocytoma

KW - Brain tumor

KW - Diffusion-weighted MRI

KW - Glioblastoma

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