Adaptive independent vector analysis for multi-subject complex-valued fMRI data

Li Dan Kuang, Qiu Hua Lin, Xiao Feng Gong, Fengyu Cong, Vince D. Calhoun

Research output: Contribution to journalArticlepeer-review

Abstract

Background Complex-valued fMRI data can provide additional insights beyond magnitude-only data. However, independent vector analysis (IVA), which has exhibited great potential for group analysis of magnitude-only fMRI data, has rarely been applied to complex-valued fMRI data. The main challenges in this application include the extremely noisy nature and large variability of the source component vector (SCV) distribution. New method To address these challenges, we propose an adaptive fixed-point IVA algorithm for analyzing multiple-subject complex-valued fMRI data. We exploited a multivariate generalized Gaussian distribution (MGGD)- based nonlinear function to match varying SCV distributions in which the MGGD shape parameter was estimated using maximum likelihood estimation. To achieve our de-noising goal, we updated the MGGD-based nonlinearity in the dominant SCV subspace, and employed a post-IVA de-noising strategy based on phase information in the IVA estimates. We also incorporated the pseudo-covariance matrix of fMRI data into the algorithm to emphasize the noncircularity of complex-valued fMRI sources. Results Results from simulated and experimental fMRI data demonstrated the efficacy of our method. Comparison with existing method(s) Our approach exhibited significant improvements over typical complex-valued IVA algorithms, especially during higher noise levels and larger spatial and temporal changes. As expected, the proposed complex-valued IVA algorithm detected more contiguous and reasonable activations than the magnitude-only method for task-related (393%) and default mode (301%) spatial maps. Conclusions The proposed approach is suitable for decomposing multi-subject complex-valued fMRI data, and has great potential for capturing additional subject variability.

Original languageEnglish (US)
Pages (from-to)49-63
Number of pages15
JournalJournal of Neuroscience Methods
Volume281
DOIs
StatePublished - Apr 1 2017

Keywords

  • Complex-valued fMRI data
  • Independent vector analysis (IVA)
  • MGGD
  • Noncircularity
  • Post-IVA phase de-noising
  • Shape parameter
  • Subspace de-noising

ASJC Scopus subject areas

  • Neuroscience(all)

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