Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma

Sara I. Pai

doi:10.4161/onci.24065

Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma

Sara I. Pai

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Human papillomavirus (HPV) variants associated with head and neck cancer generally induce a robust immune response. Despite the establishment of such an inflammatory microenvironment, HPV is able to persist and promote malignant transformation. The PD-1:PD-L1 immune checkpoint may play a critical role in the creation of an immunoprivileged site for viral persistence and the subsequent development of cancer.

Original language	English (US)
Article number	e24065
Journal	OncoImmunology
Volume	2
Issue number	5
DOIs	https://doi.org/10.4161/onci.24065
State	Published - May 2013
Externally published	Yes

Keywords

HPV
Head and neck cancer
Immune checkpoints
PD-1
PD-L1

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.24065

Cite this

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abstract = "Human papillomavirus (HPV) variants associated with head and neck cancer generally induce a robust immune response. Despite the establishment of such an inflammatory microenvironment, HPV is able to persist and promote malignant transformation. The PD-1:PD-L1 immune checkpoint may play a critical role in the creation of an immunoprivileged site for viral persistence and the subsequent development of cancer.",

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AB - Human papillomavirus (HPV) variants associated with head and neck cancer generally induce a robust immune response. Despite the establishment of such an inflammatory microenvironment, HPV is able to persist and promote malignant transformation. The PD-1:PD-L1 immune checkpoint may play a critical role in the creation of an immunoprivileged site for viral persistence and the subsequent development of cancer.

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KW - Immune checkpoints

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KW - PD-L1

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Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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