TY - GEN
T1 - Adaptive closed-loop bladder neuromodulation
AU - Peh, Wendy Y.X.
AU - Raczkowska, Marlena N.
AU - Teh, Yuni
AU - Alam, Monzurul
AU - Thakor, Nitish V.
AU - Yen, Shih Cheng
N1 - Funding Information:
This work was funded by the National Research Foundation in Singapore (NRF-CRP10-2012-01).
Publisher Copyright:
© 2017 IEEE.
PY - 2017/7/2
Y1 - 2017/7/2
N2 - Urinary retention affects millions of people, and is characterized by a weak flow of urine or high post-void residual urine volume in the bladder. In severe neurogenic bladder conditions, such as that resulting from spinal cord injury, sensation from the bladder and voluntary control of micturition are lost. Micturition can be driven by using the sacral anterior root stimulator (SARS). However, commercially available SARS devices are not equipped with a closed-loop regulator for adaptive and automated control of bladder contractions. In this study, we developed a closed-loop control strategy for bladder emptying in a rat model, achieving 86% void efficiency. Our results provide a basis for developing an implantable closed-loop neural prosthesis for treating underactive bladder in the future.
AB - Urinary retention affects millions of people, and is characterized by a weak flow of urine or high post-void residual urine volume in the bladder. In severe neurogenic bladder conditions, such as that resulting from spinal cord injury, sensation from the bladder and voluntary control of micturition are lost. Micturition can be driven by using the sacral anterior root stimulator (SARS). However, commercially available SARS devices are not equipped with a closed-loop regulator for adaptive and automated control of bladder contractions. In this study, we developed a closed-loop control strategy for bladder emptying in a rat model, achieving 86% void efficiency. Our results provide a basis for developing an implantable closed-loop neural prosthesis for treating underactive bladder in the future.
KW - adaptive stimulation
KW - bladder
KW - closed-loop neuromodulation
KW - pelvic nerve
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U2 - 10.1109/BIOCAS.2017.8325202
DO - 10.1109/BIOCAS.2017.8325202
M3 - Conference contribution
AN - SCOPUS:85050014894
T3 - 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
SP - 1
EP - 4
BT - 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2017 IEEE Biomedical Circuits and Systems Conference, BioCAS 2017
Y2 - 19 October 2017 through 21 October 2017
ER -