TY - JOUR
T1 - Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus
AU - Qadri, Firdausi
AU - Alam, Muhammad Shamsul
AU - Nishibuchi, Mitsuaki
AU - Rahman, Taufiqur
AU - Alam, Nur Haque
AU - Chisti, Jobayer
AU - Kondo, Seiichi
AU - Sugiyama, Junichi
AU - Bhuiyan, Nurul Amin
AU - Mathan, Minnie M.
AU - Sack, David A.
AU - Balakrish Nair, G.
N1 - Funding Information:
Financial support: government of Japan (special research grant to ICDDR,B); Ministry of Education, Science, Sports and Culture, Japan (grant-in-aid for scientific research). ICDDR,B is supported by countries and agencies that share its concern for the health problems of developing countries.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - In patients with diarrhea caused by Vibrio parahaemolyticus, antibody-secreting cell responses to thermostable direct hemolysin (TDH), lipopolysaccharide (LPS), and whole-cell bacteria were seen. TDH- and LPS-specific responses were seen in serum samples, and immunoglobulin A antibody responses were observed in stool. Levels of C-reactive protein and nitric oxide metabolites increased in the systemic circulation at the onset of illness. Tumor necrosis factor-α and lactoferrin levels were high during the acute stage in mucosal secretions and in plasma, whereas interleukin-1β levels were high only in mucosal secretions. Duodenal and rectal biopsy specimens obtained at the onset of illness showed an acute inflammatory response. The lamina propria showed edema, congestion of blood vessels, and hemorrhage, with an increase in levels of polymorphonudear neutrophils and macrophages. Strains belonging to different serotypes exhibited varying resistance to killing by serum; the O8:K21 strain was most sensitive. Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting.
AB - In patients with diarrhea caused by Vibrio parahaemolyticus, antibody-secreting cell responses to thermostable direct hemolysin (TDH), lipopolysaccharide (LPS), and whole-cell bacteria were seen. TDH- and LPS-specific responses were seen in serum samples, and immunoglobulin A antibody responses were observed in stool. Levels of C-reactive protein and nitric oxide metabolites increased in the systemic circulation at the onset of illness. Tumor necrosis factor-α and lactoferrin levels were high during the acute stage in mucosal secretions and in plasma, whereas interleukin-1β levels were high only in mucosal secretions. Duodenal and rectal biopsy specimens obtained at the onset of illness showed an acute inflammatory response. The lamina propria showed edema, congestion of blood vessels, and hemorrhage, with an increase in levels of polymorphonudear neutrophils and macrophages. Strains belonging to different serotypes exhibited varying resistance to killing by serum; the O8:K21 strain was most sensitive. Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting.
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U2 - 10.1086/368257
DO - 10.1086/368257
M3 - Article
C2 - 12660923
AN - SCOPUS:0037383563
SN - 0022-1899
VL - 187
SP - 1085
EP - 1096
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -