Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus

Firdausi Qadri, Muhammad Shamsul Alam, Mitsuaki Nishibuchi, Taufiqur Rahman, Nur Haque Alam, Jobayer Chisti, Seiichi Kondo, Junichi Sugiyama, Nurul Amin Bhuiyan, Minnie M. Mathan, David A. Sack, G. Balakrish Nair

Research output: Contribution to journalArticle

Abstract

In patients with diarrhea caused by Vibrio parahaemolyticus, antibody-secreting cell responses to thermostable direct hemolysin (TDH), lipopolysaccharide (LPS), and whole-cell bacteria were seen. TDH- and LPS-specific responses were seen in serum samples, and immunoglobulin A antibody responses were observed in stool. Levels of C-reactive protein and nitric oxide metabolites increased in the systemic circulation at the onset of illness. Tumor necrosis factor-α and lactoferrin levels were high during the acute stage in mucosal secretions and in plasma, whereas interleukin-1β levels were high only in mucosal secretions. Duodenal and rectal biopsy specimens obtained at the onset of illness showed an acute inflammatory response. The lamina propria showed edema, congestion of blood vessels, and hemorrhage, with an increase in levels of polymorphonudear neutrophils and macrophages. Strains belonging to different serotypes exhibited varying resistance to killing by serum; the O8:K21 strain was most sensitive. Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting.

Original languageEnglish (US)
Pages (from-to)1085-1096
Number of pages12
JournalJournal of Infectious Diseases
Volume187
Issue number7
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

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Vibrio parahaemolyticus
Adaptive Immunity
Lipopolysaccharides
Antibody-Producing Cells
Lactoferrin
Serum
Interleukin-1
C-Reactive Protein
Immunoglobulin A
Antibody Formation
Blood Vessels
Diarrhea
Edema
Nitric Oxide
Mucous Membrane
Neutrophils
B-Lymphocytes
Tumor Necrosis Factor-alpha
Macrophages
Hemorrhage

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Qadri, F., Alam, M. S., Nishibuchi, M., Rahman, T., Alam, N. H., Chisti, J., ... Balakrish Nair, G. (2003). Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus. Journal of Infectious Diseases, 187(7), 1085-1096. https://doi.org/10.1086/368257

Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus. / Qadri, Firdausi; Alam, Muhammad Shamsul; Nishibuchi, Mitsuaki; Rahman, Taufiqur; Alam, Nur Haque; Chisti, Jobayer; Kondo, Seiichi; Sugiyama, Junichi; Bhuiyan, Nurul Amin; Mathan, Minnie M.; Sack, David A.; Balakrish Nair, G.

In: Journal of Infectious Diseases, Vol. 187, No. 7, 01.04.2003, p. 1085-1096.

Research output: Contribution to journalArticle

Qadri, F, Alam, MS, Nishibuchi, M, Rahman, T, Alam, NH, Chisti, J, Kondo, S, Sugiyama, J, Bhuiyan, NA, Mathan, MM, Sack, DA & Balakrish Nair, G 2003, 'Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus', Journal of Infectious Diseases, vol. 187, no. 7, pp. 1085-1096. https://doi.org/10.1086/368257
Qadri, Firdausi ; Alam, Muhammad Shamsul ; Nishibuchi, Mitsuaki ; Rahman, Taufiqur ; Alam, Nur Haque ; Chisti, Jobayer ; Kondo, Seiichi ; Sugiyama, Junichi ; Bhuiyan, Nurul Amin ; Mathan, Minnie M. ; Sack, David A. ; Balakrish Nair, G. / Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus. In: Journal of Infectious Diseases. 2003 ; Vol. 187, No. 7. pp. 1085-1096.
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