Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus

Firdausi Qadri, Muhammad Shamsul Alam, Mitsuaki Nishibuchi, Taufiqur Rahman, Nur Haque Alam, Jobayer Chisti, Seiichi Kondo, Junichi Sugiyama, Nurul Amin Bhuiyan, Minnie M. Mathan, David A. Sack, G. Balakrish Nair

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Abstract

In patients with diarrhea caused by Vibrio parahaemolyticus, antibody-secreting cell responses to thermostable direct hemolysin (TDH), lipopolysaccharide (LPS), and whole-cell bacteria were seen. TDH- and LPS-specific responses were seen in serum samples, and immunoglobulin A antibody responses were observed in stool. Levels of C-reactive protein and nitric oxide metabolites increased in the systemic circulation at the onset of illness. Tumor necrosis factor-α and lactoferrin levels were high during the acute stage in mucosal secretions and in plasma, whereas interleukin-1β levels were high only in mucosal secretions. Duodenal and rectal biopsy specimens obtained at the onset of illness showed an acute inflammatory response. The lamina propria showed edema, congestion of blood vessels, and hemorrhage, with an increase in levels of polymorphonudear neutrophils and macrophages. Strains belonging to different serotypes exhibited varying resistance to killing by serum; the O8:K21 strain was most sensitive. Infection with V. parahaemolyticus results in B cell responses and an acute inflammatory response that is self-limiting.

Original languageEnglish (US)
Pages (from-to)1085-1096
Number of pages12
JournalJournal of Infectious Diseases
Volume187
Issue number7
DOIs
StatePublished - Apr 1 2003

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Qadri, F., Alam, M. S., Nishibuchi, M., Rahman, T., Alam, N. H., Chisti, J., Kondo, S., Sugiyama, J., Bhuiyan, N. A., Mathan, M. M., Sack, D. A., & Balakrish Nair, G. (2003). Adaptive and inflammatory immune responses in patients infected with strains of Vibrio parahaemolyticus. Journal of Infectious Diseases, 187(7), 1085-1096. https://doi.org/10.1086/368257