Adapter protein 14-3-3 is required for a presynaptic form of LTP in the cerebellum

Fatma Simsek-Duran, David J. Linden, György Lonart

Research output: Contribution to journalArticlepeer-review

Abstract

Long-term potentiation (LTP) of granule cell-Purkinje cell synapses in the mouse cerebellum requires phosphorylation by protein kinase A of the active-zone protein RIM1α at Ser413. Here, we show that the adapter protein 14-3-3 readily binds phosphorylated Ser413 in RIM1α, and that presynaptic transfection with a dominant-negative 14-3-3η mutant, or a RIM1α mutant with enhanced 14-3-3 binding, inhibits LTP. Thus, RIM1α phosphorylation triggers presynaptic LTP in part through recruitment of 14-3-3 to phospho-Ser413-RIM1α.

Original languageEnglish (US)
Pages (from-to)1296-1298
Number of pages3
JournalNature neuroscience
Volume7
Issue number12
DOIs
StatePublished - Dec 1 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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