Adaptation of HIV-1 to pigtailed macaques.

S. Gartner, Y. Liu, V. Polonis, M. G. Lewis, W. R. Elkins, E. A. Hunter, J. Miao, K. J. Corts, G. A. Eddy

Research output: Contribution to journalArticlepeer-review

Abstract

In vitro infectivity experiments were performed to assess the susceptibility of cells from various monkey species to HIV-1. T lymphocytes from pigtailed macaques, but not those from rhesus or cynomolgus monkeys, were susceptible to infection, but virus expression was limited. The majority of HIV-1 isolates were unable to productively infect pigtailed macaque cells. Inoculation of autologous, HIV-1 expressing cells led to establishment of persistent infection in pigtailed macaques as evidenced by recovery of infectious virus and development of virus-specific antibody responses.

Original languageEnglish (US)
Pages (from-to)155-163
Number of pages9
JournalJournal of Medical Primatology
Volume23
Issue number2-3
StatePublished - Feb 1994
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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