Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations

Yanhui Lu; Connie Celum; Anna Wald; Jared M. Baeten; Frances Cowan; Sinead Delany-Moretlwe; Stewart E. Reid; James P. Hughes; Ellen Wilcox; Lawrence Corey; Craig W. Hendrix

doi:10.1128/AAC.06160-11

Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations

Yanhui Lu, Connie Celum, Anna Wald, Jared M. Baeten, Frances Cowan, Sinead Delany-Moretlwe, Stewart E. Reid, James P. Hughes, Ellen Wilcox, Lawrence Corey, Craig W. Hendrix

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.

Original language	English (US)
Pages (from-to)	2777-2779
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	56
Issue number	5
DOIs	https://doi.org/10.1128/AAC.06160-11
State	Published - May 2012

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Lu, Y., Celum, C., Wald, A., Baeten, J. M., Cowan, F., Delany-Moretlwe, S., Reid, S. E., Hughes, J. P., Wilcox, E., Corey, L., & Hendrix, C. W. (2012). Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations. Antimicrobial agents and chemotherapy, 56(5), 2777-2779. https://doi.org/10.1128/AAC.06160-11

Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations. / Lu, Yanhui; Celum, Connie; Wald, Anna; Baeten, Jared M.; Cowan, Frances; Delany-Moretlwe, Sinead; Reid, Stewart E.; Hughes, James P.; Wilcox, Ellen; Corey, Lawrence; Hendrix, Craig W.

In: Antimicrobial agents and chemotherapy, Vol. 56, No. 5, 05.2012, p. 2777-2779.

Research output: Contribution to journal › Article › peer-review

Lu, Y, Celum, C, Wald, A, Baeten, JM, Cowan, F, Delany-Moretlwe, S, Reid, SE, Hughes, JP, Wilcox, E, Corey, L & Hendrix, CW 2012, 'Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations', Antimicrobial agents and chemotherapy, vol. 56, no. 5, pp. 2777-2779. https://doi.org/10.1128/AAC.06160-11

Lu, Yanhui ; Celum, Connie ; Wald, Anna ; Baeten, Jared M. ; Cowan, Frances ; Delany-Moretlwe, Sinead ; Reid, Stewart E. ; Hughes, James P. ; Wilcox, Ellen ; Corey, Lawrence ; Hendrix, Craig W. / Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations. In: Antimicrobial agents and chemotherapy. 2012 ; Vol. 56, No. 5. pp. 2777-2779.

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abstract = "Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.",

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Acyclovir achieves a lower concentration in African HIV-seronegative, herpes simplex virus 2-seropositive women than in non-African populations

Abstract

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