ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma

Gloria H. Su, Ravi Bansal, Kathleen M. Murphy, Elizabeth Montgomery, Charles J. Yeo, Ralph H. Hruban, Scott E. Kern

Research output: Contribution to journalArticle

Abstract

DPC4 is known to mediate signals initiated by type β transforming growth factor (TGFβ) as well as by other TGFβ superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFβ receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.

Original languageEnglish (US)
Pages (from-to)3254-3257
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume98
Issue number6
DOIs
StatePublished - Mar 13 2001

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