ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma

Gloria H. Su; Ravi Bansal; Kathleen M. Murphy; Elizabeth Montgomery; Charles J. Yeo; Ralph H. Hruban; Scott E. Kern

doi:10.1073/pnas.051484398

ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma

Gloria H. Su, Ravi Bansal, Kathleen M. Murphy, Elizabeth Montgomery, Charles J. Yeo, Ralph H. Hruban, Scott E. Kern

School of Medicine

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

DPC4 is known to mediate signals initiated by type β transforming growth factor (TGFβ) as well as by other TGFβ superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFβ receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.

Original language	English (US)
Pages (from-to)	3254-3257
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	98
Issue number	6
DOIs	https://doi.org/10.1073/pnas.051484398
State	Published - Mar 13 2001

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abstract = "DPC4 is known to mediate signals initiated by type β transforming growth factor (TGFβ) as well as by other TGFβ superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFβ receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.",

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AU - Bansal, Ravi

AU - Murphy, Kathleen M.

AU - Montgomery, Elizabeth

AU - Yeo, Charles J.

AU - Hruban, Ralph H.

AU - Kern, Scott E.

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AB - DPC4 is known to mediate signals initiated by type β transforming growth factor (TGFβ) as well as by other TGFβ superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFβ receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.

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ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma

Abstract

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