Acute systolic and diastolic indices of left ventricular function after cardiomyoplasty in a chronic model of heart failure

D. J. Polidori, E. B. Lankford, T. Plappert, V. A. Ferrari, M. St. John Sutton, David A Kass, M. A. Acker

Research output: Contribution to journalArticle

Abstract

Recent experimental studies have suggested that the initial nonstimulated stage of dynamic cardiomyoplasty acutely impairs ventricular function. Those investigations were performed on normal hearts and primarily examined diastolic alterations as a result of the passive muscle wrap. The purpose of this study was to assess the acute systolic and diastolic effects of a nonstimulated muscle wrap in chronic heart failure induced by rapid ventricular pacing in canines. Pressure-volume analysis of ventricular function based on conductance catheter volume and micromanometer pressure data was used. Each animal was studied before rapid pacing, before cardiomyoplasty, and immediately after wrap. By the end of the pacing period and before wrap, left ventricular dysfunction developed in all dogs, manifested by significant deterioration of both systolic and diastolic indices of ventricular function, as well as progressive increases in left ventricular volumes. However, no further deterioration with load insensitive indices of systolic or diastolic indicators of ventricular function was found as a result of the passive muscle wrap. These results suggest that the cardiomyoplasty procedure can be safely performed on failing hearts without prohibitive acute impairment of ventricular function.

Original languageEnglish (US)
JournalASAIO Journal
Volume41
Issue number3
StatePublished - 1995
Externally publishedYes

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Cardiomyoplasty
Ventricular Function
Left Ventricular Function
Heart Failure
Muscle
Muscles
Deterioration
Pressure
Catheters
Left Ventricular Dysfunction
Canidae
Animals
Dogs

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Polidori, D. J., Lankford, E. B., Plappert, T., Ferrari, V. A., St. John Sutton, M., Kass, D. A., & Acker, M. A. (1995). Acute systolic and diastolic indices of left ventricular function after cardiomyoplasty in a chronic model of heart failure. ASAIO Journal, 41(3).

Acute systolic and diastolic indices of left ventricular function after cardiomyoplasty in a chronic model of heart failure. / Polidori, D. J.; Lankford, E. B.; Plappert, T.; Ferrari, V. A.; St. John Sutton, M.; Kass, David A; Acker, M. A.

In: ASAIO Journal, Vol. 41, No. 3, 1995.

Research output: Contribution to journalArticle

Polidori, DJ, Lankford, EB, Plappert, T, Ferrari, VA, St. John Sutton, M, Kass, DA & Acker, MA 1995, 'Acute systolic and diastolic indices of left ventricular function after cardiomyoplasty in a chronic model of heart failure', ASAIO Journal, vol. 41, no. 3.
Polidori, D. J. ; Lankford, E. B. ; Plappert, T. ; Ferrari, V. A. ; St. John Sutton, M. ; Kass, David A ; Acker, M. A. / Acute systolic and diastolic indices of left ventricular function after cardiomyoplasty in a chronic model of heart failure. In: ASAIO Journal. 1995 ; Vol. 41, No. 3.
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