Acute superior oblique palsy in the monkey: effects of viewing conditions on ocular alignment and modelling of the ocular motor plant

Christian Quaia, Xiaoyan Shan, Jing Tian, Howard Ying, Lance M. Optican, Mark Walker, Rafael J Tamargo, David Samuel Zee

Research output: Contribution to journalArticle

Abstract

We investigated the immediate and long-term changes in static eye alignment with acute superior oblique palsy (SOP) in the monkey. When the paretic eye was patched immediately after the lesion for 6-9 days, vertical alignment slowly improved. When the patch was removed and binocular viewing was allowed, alignment slowly worsened. In contrast when a monkey was not patched immediately after the lesion vertical alignment did not improve. We also show that a model of the eye plant can reproduce the observed acute deficit induced by SOP, but only by abandoning Robinson's symmetric simplification of the reciprocal innervation relationship within pairs of agonist-antagonist muscles. The model also demonstrated that physiologic variability in orbital geometry can have a large impact on SOP deficits.

Original languageEnglish (US)
Pages (from-to)47-52
Number of pages6
JournalProgress in Brain Research
Volume171
DOIs
StatePublished - 2008

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Keywords

  • adaptation
  • eye movements
  • eye plant
  • ocular motor
  • strabismus
  • superior oblique palsy

ASJC Scopus subject areas

  • Neuroscience(all)

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