Acute superior oblique palsy in the monkey: effects of viewing conditions on ocular alignment and modelling of the ocular motor plant

Christian Quaia, Xiaoyan Shan, Jing Tian, Howard Ying, Lance M. Optican, Mark Walker, Rafael Tamargo, David S. Zee

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We investigated the immediate and long-term changes in static eye alignment with acute superior oblique palsy (SOP) in the monkey. When the paretic eye was patched immediately after the lesion for 6-9 days, vertical alignment slowly improved. When the patch was removed and binocular viewing was allowed, alignment slowly worsened. In contrast when a monkey was not patched immediately after the lesion vertical alignment did not improve. We also show that a model of the eye plant can reproduce the observed acute deficit induced by SOP, but only by abandoning Robinson's symmetric simplification of the reciprocal innervation relationship within pairs of agonist-antagonist muscles. The model also demonstrated that physiologic variability in orbital geometry can have a large impact on SOP deficits.

Original languageEnglish (US)
Title of host publicationUsing Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever
PublisherElsevier
Pages47-52
Number of pages6
ISBN (Print)9780444531636
DOIs
StatePublished - 2008

Publication series

NameProgress in Brain Research
Volume171
ISSN (Print)0079-6123

Keywords

  • adaptation
  • eye movements
  • eye plant
  • ocular motor
  • strabismus
  • superior oblique palsy

ASJC Scopus subject areas

  • Neuroscience(all)

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