Acute salt loading and cardiotonic steroids in resistant hypertension

Igor V. Emelyanov, Alexandra O. Konradi, Edward G. Lakatta, Olga V. Fedorova, Alexei Y. Bagrov

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The study addresses the association of marinobufagenin (MBG), a natriuretic and vasoconstrictor steroid, and Na/K-ATPase (NKA) activity with pressor response to salt-loading and arterial stiffness in resistant hypertension (RH). Thirty-four patients (18 males and 16 females; 56 ± 8 years) with RH on a combined (lisnopril/amlodipine/hydrochlorothiazide) therapy and 11 healthy age-matched normotensive subjects (7 males and 4 females; 54 ± 2 years) were enrolled in this study. Salt-loading was performed via intravenous infusion of 1000 mL saline (0.9% NaCl) for 1 h. Arterial stiffness was measured by Sphygmocor Px device with a calculation of pulse-wave velocity (PWV). Activity of NKA was measured in erythrocytes. We demonstrated that plasma levels of MBG and magnitude of NaCl-induced MBG-dependent NKA inhibition are associated with PWV, and that this association has gender- and age-specific fashion in RH patients.

Original languageEnglish (US)
Title of host publicationCurrent Topics in Membranes
EditorsSergei N. Orlov
PublisherAcademic Press Inc.
Pages1-13
Number of pages13
ISBN (Print)9780128177648
DOIs
StatePublished - 2019
Externally publishedYes

Publication series

NameCurrent Topics in Membranes
Volume83
ISSN (Print)1063-5823

Keywords

  • Aging
  • Gender
  • Inhibitors
  • Marinobufagenin
  • Na/K-ATPase
  • NaCl dietary
  • Pulse-wave velocity
  • Resistant hypertension

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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